Stress Granules Ease the Way for Cancer Metastasis
Somasekharan et al., 2015 Fewer stress granules (yellow) occur in cancer cells lacking G3BP1 (right) than in controls (left). Nuclei are labeled blue.
When cells are under duress, they curtail almost all protein synthesis and stash their mRNAs in stress granules. These structures help healthy cells, but they also allow tumor cells to survive harsh conditions. A protein named YB-1, which is overexpressed in many types of tumors, accumulates in stress granules, but researchers don’t know how YB-1 affects these particles.
University of British Columbia scientist Poul Sorensen and his colleagues found that stressed-out cancer cells need YB-1 to assemble stress granules. Removing YB-1 decreased levels of one stress granule protein, G3BP1. The team discovered that YB-1 attaches to the mRNA encoding G3BP1 and stimulates the protein’s production.
To determine the effects of YB-1 in animals, the researchers implanted mice with cancer cells that either made or lacked the protein. A month later, cells in the control tumors carried more stress granules than did the tumor cells missing YB-1.
Sorensen and colleagues then implanted mice with tumors that either produced or lacked G3BP1. The control tumors harbored more stress granules than did the G3BP1-deficient tumors, and only the control tumors metastasized.
Further research is needed to find out how the reduction in stress granules curbs metastatic spread, but the results suggest that inhibiting their formation might be a way to curb cancer metastasis.
Somasekharan, S.P., et al. 2015. J. Cell Biol. doi:10.1083/jcb.201411047
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Research reported in the press release was supported by the Terry Fox Research Institute, Prostate Cancer Canada-Movember Foundation, German Research Foundation , and British Columbia Cancer Foundation.
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