PEN – Efficient and catalytic formation of highly substituted Pyrazoles by Enamines and Nitriles
Scientist at the Westfälische Wilhelms University of Münster developed the efficient Cu-catalyzed PEN method for the formation of tetra-substituted pyrazoles. In this atomeconomic process, readily available enamines and nitriles are reacted by C-C and N-N bond formation. A broad scope of enamines and nitriles can be utilized in this process.
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