PET-tracer-based visualization of the intensity and localization of peripheral longlasting pain

Pain is probably the most common symptom and sensation of a disease, and a big individual and socioeconomic challenge. Diagnostic tools are limited and do not result in clear mechanism-based insight into the etiology of the individual pain. PET-tracers are widely used as diagnostic and therapeutic tools in several types of cancer, besides other applications of visualization in various medical indications. However, there are so far only few reports, which utilize PET-tracer and PET-scan for the detection of pain (see references). The inventors have provided proof that an established PET-tracer for use in cancer can be also utilized for the detection of pain as a second medical application. They found this tracer to be enriched at the peripheral site of pain (see figure). The amount of tracer-enrichment strongly correlated with the measured change in pain sensitivity. On behalf of the University of Cologne and of the Witten/Herdecke University, PROvendis offers access to rights for commercial use as well as the opportunity for further co-development and evaluation.

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