Multiple orthogonal labelling of oligonucleotides
Labeled oligonucleotides are used in research and for diagnostic, therapeutic and industrial applications. Researchers from the DKFZ and the Heidelberg University developed a fast method for post-synthetic multiple orthogonal labeling of oligonucleotides by combining the inverse Diels-Alder reaction with the well-known copper-catalyzed azide-alkyne cycloaddition.
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DKFZ (German Cancer Research Center, Deutsches Krebsforschungszentrum)
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