Short N terminus Split Inteins – Novel Split Inteins for protein semisynthesis and protein coupling

Protein trans-splicing catalyzed by split inteins is a powerful technique for Assembling a polypeptide backbone from two separate parts. As shown in the figure, the N and C terminal intein fragments associate and fold into the active domain thereby linking the
flanking sequences with a peptide bond. However, split inteins with robust efficiencies and short fragments suitable for Peptide synthesis are rare and have mostly been artificially created exhibiting poor to moderate coupling efficiencies only.

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