Temperature perception influences protein degradation and lifespan
A wild-type worm perceives elevated temperature through sensory neurons (red) and adjusts its protein degradation in the gut. A mutant that lacks functional sensory neurons (no red signal) can't perceive warm temperature correctly and fails to adjust its protein degradation in the gut resulting in elevated protein levels (green).
Credit: University of Cologne
Proteins in the gut of the nematode C. elegans are not degraded when its temperature sensors are disturbed / At the same time, the worm’s lifespan is extended.
Scientists from the group of Professor Dr. Thorsten Hoppe at the Cologne Cluster of Excellence for Aging Research CECAD have found that in the nematode C. elegans, the perception of changes in ambient temperature via a defined network of sensory neurons is important for the maintenance of protein degradation in the gut. While wild-type worms increase their protein degradation in response to elevated temperature, worms lacking the perception of elevated temperature due to a mutation do not adjust their protein degradation rate while showing an extended lifespan.
The researchers published their findings in the article “Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling” in Nature Communications.
To maintain and improve their chances of survival, organisms must constantly adapt to changing environmental conditions.
The perception of the external environment is mediated by sensory neurons and is crucial for maintaining the balance of physiological body functions, known as homeostasis. Cellular protein homeostasis is achieved by maintaining a complex balance between protein synthesis, protein folding, and protein degradation. Dysregulation of protein homeostasis is associated with a variety of age-related protein folding diseases, in which misfolded proteins are not degraded and accumulate in cells, which can affect neuronal functionality as well.
The authors used the nematode C. elegans to investigate how a general impairment of environmental perception affects protein degradation. To do this, they used worms whose sensory neurons, by means of mutations in genes that control the functionality of these neurons, are impaired. They found that specifically, the perception of changes in ambient temperature via a defined network of sensory neurons is important for maintaining protein degradation in the gut via the insulin-like signalling factor INS-5 and the calcineurin-signalled FOXO transcription factor DAF-16.
While wild-type worms increase their protein degradation in response to elevated temperature, worms lacking the perception of elevated temperature do not adjust their protein degradation rate while exhibiting an extended lifespan.
“According to this, it is not the temperature in the organism’s environment per se that influences protein degradation and the lifespan of the nematode, but rather it is the neuronal perception and processing of temperature stimuli that adjusts its protein degradation,” says first author Dr. Alexandra Segref.
In light of current climate changes, it is of importance to determine how a chronic increase in temperature affects these signalling pathways and thus protein degradation and lifespan in higher organisms.
“Interestingly, neurological damage in patients with neurodegenerative diseases can be reduced or even averted by severe cooling of the brain, however it is still completely unclear how this works. Our data suggest that the degradation of proteins as a consequence of the perception of temperature stimuli is an important factor that could be therapeutically relevant,” speculates Professor Dr Thorsten Hoppe.
Media Contact:
Professor Dr Thorsten Hoppe
Dr Alexandra Segref
CECAD – Cellular Stress Responses in Aging-Associated Diseases
+49 221 478 84218
+49 221 478 84215
thorsten.hoppe@uni-koeln.de
asegref@uni-koeln.de
Press and Communications Team:
Robert Hahn
+49 221 470 3107
r.hahn@verw.uni-koeln.de
Publication:
https://www.nature.com/articles/s41467-022-33467-7
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