A recent paper published in Engineering titled “Machine Memory Intelligence: Inspired by Human Memory Mechanisms” explores a novel approach to AIby drawing inspiration from the human brain’s memory mechanisms. This research aims to address the limitations of current large models, such as ChatGPT, and paves the way for the development of more efficient and intelligent machines. Large models have achieved remarkable performance in various fields but suffer from several drawbacks. They consume excessive amounts of data and computing power, are prone to…
Cytochrome P450 (CYP) proteins are responsible for breaking down more than 80% of all Food and Drug Administration (FDA) approved drugs, reducing their effectiveness. However, how to prevent CYPs from doing this without off-target effects has puzzled researchers until now. Scientists at St. Jude Children’s Research Hospital have designed new drug frameworks that selectively target CYP3A4, one of the most critical CYP proteins. Structural insights from this work offer a roadmap for future drug developers to better evaluate drug interactions and selectively…
In a groundbreaking study published in Science, a research team led by Prof. YE Jian from the Institute of Microbiology of the Chinese Academy of Sciences has identified the first mechanism of citrus resistance to citrus greening disease, or huanglongbing (HLB). Utilizing artificial intelligence (AI), the team has also developed antimicrobial peptides that offer a promising therapeutic approach to combat the disease. This discovery addresses a long-standing challenge in the agricultural community—the absence of naturally occurring HLB-resistant genes in citrus….
Study in mice shows motivation can be restored with targeted treatments The fatigue and lack of motivation that many cancer patients experience near the end of life have been seen as the unavoidable consequences of their declining physical health and extreme weight loss. But new research from Washington University School of Medicine in St. Louis challenges that long-held assumption, showing instead that these behavioral changes stem from specific inflammation-sensing neurons in the brain. In a study published April 11 in…
The research groups led by Wolfgang Kastenmüller and Georg Gasteiger employed innovative microscopy techniques to observe how specific immune cells, known as T-cells, are activated and proliferate during a viral infection. Their findings revealed novel mechanisms: the immune system amplifies its defense cells in a far more targeted way than previously believed. T-Cells Proliferate and Specialize During the Immune Response T-cells are crucial defense cells in the immune system. To effectively find and destroy infected cells in the body, rare…
Researchers have discovered antiferromagnetism in a real icosahedral quasicrystal, reinvigorating the search for antiferromagnetic quasicrystals Quasicrystals (QCs) are fascinating solid materials that exhibit an intriguing atomic arrangement. Unlike regular crystals, in which atomic arrangements have an ordered repeating pattern, QCs display long-range atomic order that is not periodic. Due to this ‘quasiperiodic’ nature, QCs have unconventional symmetries that are absent in conventional crystals. Since their Nobel Prize-winning discovery, condensed matter physics researchers have dedicated immense attention towards QCs, attempting to…
Although we know that supermassive black holes (millions of times the mass of our Sun) lurk at the centre of most galaxies, their very nature makes them difficult to spot and study. In contrast to the popular idea of black holes constantly ‘gobbling up’ matter, these gravitational monsters can spend long periods of time in a dormant, inactive phase. This was true of the black hole at the heart of SDSS1335+0728, a distant and unremarkable galaxy 300 million light-years away…
Capturing carbon dioxide (CO₂) from industrial emissions is crucial in the fight against climate change. But current methods, like chemical absorption, are expensive and energy-intensive. Scientists have long eyed graphene—an atom-thin, ultra-strong material—as a promising alternative for gas separation, but making large-area, efficient graphene membranes has been a challenge. Now, a team at EPFL, led by Professor Kumar Agrawal, has developed a scalable technique to create porous graphene membranes that selectively filter CO₂ from gas mixtures. Their approach slashes production…
A study reveals emotional empathy and depression as key factors in intergenerational childhood maltreatment, offering pathways for intervention Childhood maltreatment (CM) is a complex issue that is often passed on through generations. Studies have shown that parents who were abused as children may perpetuate a similar pattern of mistreating their children, creating a vicious cycle of abuse. A key factor in perpetuating this cycle is impaired empathy in parents who grew up in abusive environments. Simply put, parental empathy, the…
A research team from Helmholtz Munich and the Technical University of Munich has developed an advanced delivery system that transports gene-editing tools based on the CRISPR/Cas9 gene-editing system into living cells with significantly greater efficiency than before. Their technology, ENVLPE, uses engineered non-infectious virus-like particles to precisely correct defective genes – demonstrated successfully in living mouse models that are blind due to a mutation. This system also holds promise for advancing cancer therapy by enabling precise genetic manipulation of engineered…
A team of researchers led by Nathan Clark of the Vrije Universiteit Amsterdam, in partnership with the Research Institute for Sustainability (RIFS), has unveiled a comprehensive set of recommendations aimed at strengthening Europe’s resilience to disasters. Their published findings emphasize the importance of grounding disaster preparedness in both scientific research and practical application. The authors warn in their article “Strengthening all-of-society approaches for disaster resilient societies through competency building: A European research agenda” that societies face an increasingly complex and…
Scientists build ‘digital twin’ of mouse brain Much as a pilot might practice maneuvers in a flight simulator, scientists might soon be able to perform experiments on a realistic simulation of the mouse brain. In a new study, Stanford Medicine researchers and collaborators used an artificial intelligence model to build a “digital twin” of the part of the mouse brain that processes visual information. The digital twin was trained on large datasets of brain activity collected from the visual cortex…
Scientists from Johannes Gutenberg University Mainz (JGU) are among the thousands of researchers worldwide honored with the 2025 Breakthrough Prize in Fundamental Physics, awarded to the ATLAS Collaboration at CERN’s Large Hadron Collider (LHC) alongside its sister experiments ALICE, CMS and LHCb. The prize was awarded during a ceremony of the Breakthrough Prize Foundation held in Los Angeles on 5 April. ATLAS is one of the largest and most complex scientific instruments ever built. As a general-purpose particle detector measuring…
The development of new antibiotics to treat superbugs and other bacterial infections is a global priority, with the rate of infections that cannot be treated with current antibiotics rising and presenting one of the biggest threats to human health. In line with that, new research has shown a daily dose of epidermicin NI01 – an antibiotic compound developed by University of Plymouth spinout company Amprologix – is as effective at removing Methicillin-resistant Staphylococcus aureus (MRSA) as the current standard of…
Lacquers, paint, concrete—and even ketchup or orange juice: Suspensions are widespread in industry and everyday life. By a suspension, materials scientists mean a liquid in which tiny, insoluble solid particles are evenly distributed. If the concentration of particles in such a mixture is very high, phenomena can be observed that contradict our everyday understanding of a liquid. For example, these so-called non-Newtonian fluids suddenly become more viscous when a strong force acts upon them. For a brief moment, the liquid…
Urgent action is needed to protect endangered species, human health and industry from the impacts of the Caspian Sea shrinking, research led by the University of Leeds has found. Water levels in the Caspian Sea – the world’s largest landlocked water body – are getting lower, as hotter temperatures cause more water to evaporate than is flowing in. Even if global warming is limited to below 2°C, it is likely that the level of the Caspian Sea will decline by 5…
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