Big leap for regenerative medicine to treat ageing but intact skeletal muscle  Tokyo, Japan – Researchers from Tokyo Metropolitan University have developed a way to treat ageing-related muscular atrophy using regenerative medicine. Conventional methods to implant myoblasts, precursors to muscle fiber, required prior scarring for the new cells to graft properly. By adding extracellular matrix (ECM) fluid into the implant, the team successfully grafted myoblasts onto healthy muscle in mice. Their technique opens the way for using implantation to treat…

UFZ researchers detect microscopic plastic particles on alpine glaciers with the help of mountaineers Nanoplastics – plastic particles smaller than 1 µm – are widely dispersed because of their low weight. A research team coordinated by the Helmholtz Centre for Environmental Research (UFZ) has now published an article in Scientific Reports that shows the extent to which glaciers at an altitude of more than 3,000 m in the Alps are polluted by nanoplastics. The researchers relied on citizen science to…

Called PAC-MANN, the test developed at OHSU could help save lives  A new blood test could help doctors detect pancreatic cancer earlier, potentially improving survival rates for one of the deadliest cancers. Researchers at Oregon Health & Science University have developed a test called PAC-MANN, the abbreviation for “protease activity-based assay using a magnetic nanosensor,” which uses a small blood sample to detect changes in protease activity — a key indicator of pancreatic ductal adenocarcinoma, or PDAC, the most common…

Researchers find a master epigenetic switch that activates silenced genes to compensate for their missing counterparts in a rare genetic disease called Prader-Willi syndrome  Biomedical engineers at Duke University have demonstrated a promising new approach that could be used to treat a rare and complex class of genetic diseases caused by defects in a relatively large region of the genome. By identifying and activating a master epigenetic switch using CRISPR, the researchers showed they can turn on many naturally suppressed…

Endometriosis, a prevalent gynecological condition, is characterized by the growth of endometrial-like tissues outside the uterus, leading to severe pain and infertility in affected women. The pathogenesis of endometriosis remains elusive, and effective treatments are limited, highlighting the need for a deeper understanding of its molecular mechanisms. A pivotal role of P21-activated kinase 5 (PAK5) in endometriosis progression has been uncovered, revealing that PAK5-mediated phosphorylation of pyruvate kinase M2 (PKM2) is critical for anaerobic glycolysis in endometriotic cells. This discovery…

Accumulation of fat molecules is detrimental to the cell. Researchers from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), have made a breakthrough in understanding how our cells manage to stay healthy by recycling important fat molecules. Their study, published in the journal Proceedings of the National Academy of Sciences (PNAS), reveals how a protein called Spinster homolog 1 (Spns1) helps transport fats out of cell compartments known as lysosomes. Led by Associate Professor Nguyen…

El Camino Health successfully pilots an innovative Women’s Heart Center  According to the U.S. Physician Workforce Data Dashboard, only about 17% of cardiologists are women, ranking as one of the lowest specialties among female physicians, yet heart disease remains the number one killer of women, accounting for one in five female deaths. El Camino Health is innovating a solution to address the unique symptoms and risk factors of heart disease in women. A new national survey conducted by El Camino…

ISTA scientists uncover how the brain unblurs vision during movement  Why do our mental images stay sharp even when we are moving fast? A team of neuroscientists led by Professor Maximilian Jösch at the Institute of Science and Technology Austria (ISTA) has identified a mechanism that corrects visual distortions caused by movement in animals. The study, conducted in mice, identifies a core function that can be generalized across the vertebrate visual system, including primates such as humans. The findings are…

Adults with high levels of playfulness showed strong resilience during the COVID-19 pandemic compared to less playful individuals, new research shows. The study led by Xiangyou “Sharon” Shen of Oregon State University is important because playfulness is a vital but underappreciated resource for building resilience and maintaining well-being during difficult periods such as the pandemic, Shen said. And it’s a resource that individuals can cultivate. “Understanding how playful people navigate adversity can inform interventions and strategies to help people cope…

A hedonic price model incorporating street view images processed by machine learning and existing property data achieves nearly 75% accuracy for rent prediction in Osaka City  Housing rents usually correlate with factors such as the building’s age, facilities, and location. Yet not all rentals with similar physical factors charge the same rent. Psychological factors such as the subjective perceptions of the neighborhood matter as well. Considering these perception variables, an Osaka Metropolitan University team has developed a method with almost…

Cretaceous fossil from Antarctica reveals earliest modern bird New clues delve into the age-old question: Does a duck always look like a duck and quack like a duck? Sixty-six million years ago, at the end of the Cretaceous Period, an asteroid impact near the Yucatán Peninsula of Mexico triggered the extinction of all known non-bird dinosaurs. But for the early ancestors of today’s waterfowl, surviving that mass extinction event was like… water off a duck’s back. Location matters, as Antarctica…

Globally, women’s workforce participation is about 25% lower than men’s, often due to barriers such as domestic responsibilities and cultural norms. Vocational training can increase employment opportunities, but women may not be able to attend training programs that require them to be away from home. A new study from the University of Illinois Urbana-Champaign, in collaboration with an international research team, explored whether hybrid distance learning can improve accessibility to job training for rural women in Nepal. “We had been working in…

A study of fruit flies shows some species are highly susceptible to a wide range of viruses. In the study – by the University of Exeter – 35 fruit fly species were exposed to 11 different viruses of diverse types. As expected, fly species that were less affected by a certain virus also tended to respond well to related viruses. But the findings also show “positive correlations in susceptibility” to viruses in general. In other words, fly species that were…

UMD researchers uncover key mechanisms in gene regulation that may lead to better design of RNA-based medicines.  RNA-based medicines are one of the most promising ways to fight human disease, as demonstrated by the recent successes of RNA vaccines and double-stranded RNA (dsRNA) therapies. But while health care providers can now successfully develop drugs that use dsRNA to accurately target and silence disease-causing genes, a major challenge remains: getting these potentially life-saving RNA molecules into cells efficiently. A new study published in…

A new drug-free, minimally invasive intervention targets the root cause of progressive loss of neural function in spinal muscle atrophy (SMA), an inherited neuromuscular disease. An intervention, which involves electrical stimulation of the sensory spinal nerves, can gradually reawaken functionally silent motor neurons in the spinal cord and improve leg muscle strength and walking in adults with SMA. The findings were reported by University of Pittsburgh School of Medicine researchers in Nature Medicine today. Early results from a pilot clinical…

A new international study highlights the severity of climate change impacts across African mountains, how farmers are adapting, and the barriers they face – findings relevant to people living in mountain regions around the world. “Mountains are the sentinels of climate change,” said Julia Klein, a Colorado State University professor of ecosystem science and sustainability and co-author of the study. “Like the Arctic, some of the first extreme changes we’re seeing are happening in mountains, from glaciers melting to extreme…