Campylobacter jejuni-specific antibody gives hope to vaccine development
These spiral rod-shaped bacteria are a leading cause of enteritis, sometimes leading to diarrheal and extra-intestinal infectious mortality in children under 5 and elderly persons, respectively.
Credit: Osaka Metropolitan University
By targeting multiprotein molecule, antibody inhibits bacteria’s growth, pathogenicity.
Bacterial infections resulting in enteritis, sometimes extra-intestinal infections such as sepsis, continue to be a global health concern. A leading cause of diarrheal and extra-intestinal infectious mortality among children under 5 and elderly persons is infection with Campylobacter bacteria, against which there is no effective vaccine or medication. An Osaka Metropolitan University-led team has recently uncovered what could be an important step toward preventing, diagnosing, and treating a species of Campylobacter bacteria.
Researchers including Professor Shinji Yamasaki and Associate Professor Noritoshi Hatanaka of the Graduate School of Veterinary Science and the Osaka International Research Center for Infectious Diseases at OMU focused on Campylobacter jejuni, the species of the bacteria that commonly causes gastroenteritis and sometimes extra-intestinal infections. Together they developed an antibody that can identify C. jejuni and inhibit the bacteria’s growth.
This monoclonal antibody reacts to a multiprotein complex known as QcrC, the expression of which is essential for the pathogenicity of C. jejuni. The QcrC molecule was found in multiple C. jejuni strains, lending high reliability to the antibody’s use in identifying the species. This molecule is also involved in energy production for C. jejuni, and the antibody acts to suppress this function, slowing the bacteria’s growth and decreasing pathogenicity.
“Our findings can lead to the development of preventive approaches so that Campylobacter infections do not become more severe, while also formulating a simple way to detect C. jejuni,” Associate Professor Hatanaka stated.
“The development of a simple detection system,” Professor Yamasaki explained, “will be useful for the rapid identification of contaminated food, which will be beneficial for the control of C. jejuni infections and food poisoning, along with vaccine development.”
The findings were published in Frontiers in Microbiology.
About OMU
Established in Osaka as one of the largest public universities in Japan, Osaka Metropolitan University is committed to shaping the future of society through “Convergence of Knowledge” and the promotion of world-class research. For more research news, visit https://www.omu.ac.jp/en/ and follow us on social media: X, Facebook, Instagram, LinkedIn.
Journal: Frontiers in Microbiology
DOI: 10.3389/fmicb.2024.1415893
Method of Research: Experimental study
Subject of Research: People
Article Title: QcrC is a potential target for antibody therapy and vaccination to control Campylobacter jejuni infection by suppressing its energy metabolism
Article Publication Date: 2-Jul-2024
COI Statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Media Contact
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Osaka Metropolitan University
koho-ipro@ml.omu.ac.jp
Office: +81-6-6605-3452
@OsakaMetUniv_en
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