Heart Surgery Risks: Low BP Linked to Postoperative Kidney Injury

First large cohort study at the Heart and Diabetes Center NRW awarded – Hilke Jung presents research project at the FoRUM conference of the Ruhr University Bochum

A working group led by Prof. Dr. Vera von Dossow, Director of the Institute for Anaesthesiology and Pain Therapy at the Heart and Diabetes Center NRW (HDZ NRW), Bad Oeynhausen, has now demonstrated for the first time in a large retrospective cohort study that longer and more frequent phases of intraoperatively low blood pressure during cardiac surgery can be cumulatively associated with a higher risk of the occurrence of postoperative kidney failure.

Study Overview: Investigating Intraoperative Hypotension in Cardiac Surgery

The study included 28,909 patients who underwent elective cardiac surgery at the HDZ NRW between 2009 and 2019. An intraoperative hypotension phase was defined as intraoperatively measured arterial blood pressure of less than 60 mmHg for more than two minutes. The cumulative duration and frequency of intraoperative hypotension that occurred had a significant influence on the occurrence of acute kidney injury. Other influencing factors included the duration and type of surgery, age, body mass index and concomitant diseases. This has never been demonstrated in such a large patient population before.

Implications for Patient Safety and Future Research

“We hope that these important findings will contribute to improving patient safety and the quality of care. These results were collected retrospectively from a large patient population. Nevertheless, they underline the importance of close intraoperative blood pressure control. To date, there have been no prospective randomized studies in cardiac surgery. Such projects are therefore among the other projects of our working group for early risk stratification and strategy planning (ERSAS),” emphasized Prof. Dr. Vera von Dossow and PD Dr. Nikolai Hulde, who supervised the dissertations of Niklas Mohr and Hilke Jung at the Ruhr University Bochum as part of the research project.

Recognition for Outstanding Scientific Contribution

For the presentation of her published doctoral project during the FoRUM scientific conference of the Ruhr University Bochum, Hilke Jung received the second prize for young scientists, the so-called “Young Science Best Medical Paper Award 2024.”

About the Heart and Diabetes Center North Rhine-Westphalia (HDZ NRW)

As a specialist clinic for the treatment of cardiac, circulatory and diabetes diseases, the Heart and Diabetes Center North Rhine-Westphalia (HDZ NRW) in Bad Oeynhausen is one of the largest and most modern centers of its kind in Europe, with 36,000 patients annually, of which 14,500 are inpatients. The HDZ NRW has been a university clinic of the Ruhr University Bochum since 1989. The professors of the HDZ NRW have also been members of the OWL Medical Faculty of Bielefeld University since 2023. The facility is known as the largest heart transplant center in Germany. The shareholder is the state of North Rhine-Westphalia.

Expertise in Anaesthesiology and Pain Therapy

At the Institute for Anaesthesiology and Pain Therapy under the direction of Prof. Dr. Vera von Dossow, more than 7,000 anesthetics are performed on patients every year. Distinctive specialist skills, many years of expertise and trusting interdisciplinary teamwork guarantee the greatest possible safety when administering anesthesia to patients of all ages, especially high-risk patients.

Further information
Heart and Diabetes Center North Rhine-Westphalia
University Hospital of the Ruhr University Bochum
Medical Faculty OWL (University of Bielefeld)
Website address: www.hdz-nrw.de

Scientific contacts
Univ.-Prof. Dr. med. Vera von Dossow
Director of the Institute for Anaesthesiology and Pain Therapy
Heart and Diabetes Center NRW, Bad Oeynhausen

Original publication
Young, Hilke; Mohr, Niklas; Hulde, Nikolai; Krannich, Alexander; Storm, Christian; Von Dossow
Article Title: Intraoperative hypotension and its association with acute kidney injury in patients undergoing elective cardiac surgery: a large retrospective cohort study.
Journal: European Journal of Anesthesiology and Intensive Care
Article Publication Date: April 2024
DOI: 10.1097/EA9.0000000000000048

Media contact
Anna Reiss, Press Officer
Georgstr. 11
32545 Bad Oeynhausen
Phone Number: 05731 97-1955
Fax: 05731 97-2028
E-Mail: info@hdz-nrw.de

Source: (IDW)