Vaccine shows promise for kidney cancer

Results of a phase III study from Germany in this week’s issue of THE LANCET suggest that a tumour-based vaccine could reduce disease recurrence and increase survival of patients who have had surgery for kidney cancer.

3% of cancer occurs in the kidney, with around 12,000 renal-cancer deaths a year in the USA. Removal of part or all of the kidney (nephrectomy) is the standard treatment for renal cancer, although other treatments after surgery (eg, radiotherapy, chemotherapy) are not effective. Around half of patients with renal cancer will have disease recurrence within 5 years.

Dieter Jocham from the University of Lubeck Medical School, Germany, and colleagues studied 558 patients from 55 medical centres in Germany with a renal tumour scheduled for nephrectomy. Before surgery, all patients were randomised to receive autologous renal tumour cell vaccine (six injections in the upper arm at 4-week intervals after surgery; the vaccine group) or no additional treatment (the control group).

Data were available for 379 patients. 5-year progression-free survival rates were 77% in the vaccine group and 68% in the control group. The vaccine was well tolerated, with only 12 adverse events associated with the treatment. The authors conclude that the vaccine can now be considered for renal cancer patients with tumours larger than 2.5 cm who have undergone nephrectomy.

Referring to Jocham and colleagues’ study as an ‘immunological breakthrough’, Mayer Fishman and Scott Antonia from H Lee Moffitt Cancer Center and Research Institute, Tampa, USA, state in an accompanying Commentary (p 583): ‘‘[Jocham and colleagues’] carefully collected data are part of a broadening base of clinical observations of the potential to affect the biology of a solid tumour with non-toxic readministration of autologous tumour-derived material’ The key milestone is the suggestion of a fixed point-a non-toxic vaccine with a biological clinically relevant effect in T2-3N0 renal cancer-around which innovations can be built. Such a milestone can serve as a concrete step towards making adjuvant treatment of renal cancer a routine and effective intervention.’

Media Contact

Richard Lane alfa

More Information:

http://www.thelancet.com

All latest news from the category: Health and Medicine

This subject area encompasses research and studies in the field of human medicine.

Among the wide-ranging list of topics covered here are anesthesiology, anatomy, surgery, human genetics, hygiene and environmental medicine, internal medicine, neurology, pharmacology, physiology, urology and dental medicine.

Back to home

Comments (0)

Write a comment

Newest articles

First-of-its-kind study uses remote sensing to monitor plastic debris in rivers and lakes

Remote sensing creates a cost-effective solution to monitoring plastic pollution. A first-of-its-kind study from researchers at the University of Minnesota Twin Cities shows how remote sensing can help monitor and…

Laser-based artificial neuron mimics nerve cell functions at lightning speed

With a processing speed a billion times faster than nature, chip-based laser neuron could help advance AI tasks such as pattern recognition and sequence prediction. Researchers have developed a laser-based…

Optimising the processing of plastic waste

Just one look in the yellow bin reveals a colourful jumble of different types of plastic. However, the purer and more uniform plastic waste is, the easier it is to…