Turning the enemy into a friend
Sounds paradoxical: varicella zoster virus spreads better in the body by enhancing an immune defence mechanism.
Varicella zoster virus (VZV) can cause chickenpox, as well as shingles and severe complications. When one comes into contact with VZV for the first time, the virus enters the body through the airways, reaching the mucous membranes in the nasopharynx and adjacent lymphatic tissues, from where VZV infects T lymphocytes. In these immune cells, VZV spreads throughout the body, reaching skin cells – resulting in chickenpox – and neurons, where it remains latent. If VZV becomes active again later in life, it causes shingles.
To defend against VZV, the body produces interferons, among other things. However, this defence only works to a limited extent. Researchers led by Prof. Abel Viejo-Borbolla at the Institute of Virology of Hannover Medical School (MHH) have now studied how the virus manages to escape this defence mechanism. The result sounds paradoxical: the virus does not weaken the immune response, but rather specifically enhances it for its own advantage. The research team published their findings in the prestigious journal Nature Communications.
“The glycoprotein C of VZV binds in particular to interferon gamma. This leads to modulation of the signals triggered by this cytokine, resulting in increased production of certain proteins, for example the intercellular adhesion molecule 1,” explains Dr. Carina Jacobsen, first author of the article. This molecule promotes cell adhesion and thus T cells bind more easily to the infected skin cells and more virions can be transferred from the skin cells to the immune cells. In a sense, the virus has then managed to mount the Trojan horse – in order to spread throughout the body.
The research results form the basis for the development of new drugs against these and possibly other viruses.
The scientific publication “Viral modulation of type II interferon increases T cell adhesion and virus spread” can be found here: https://www.nature.com/articles/s41467-024-49657-4
https://www.mhh.de/en/presse/mhh-insight/news-detailed-view/turning-the-enemy-into-a-friend
Media Contact
All latest news from the category: Health and Medicine
This subject area encompasses research and studies in the field of human medicine.
Among the wide-ranging list of topics covered here are anesthesiology, anatomy, surgery, human genetics, hygiene and environmental medicine, internal medicine, neurology, pharmacology, physiology, urology and dental medicine.
Newest articles
Successful experiment paves the way for new element
Scientists have found an alternative way to produce atoms of the superheavy element livermorium. The new method opens up the possibility of creating another element that could be the heaviest…
A new spectroscopy reveals water’s quantum secrets
For the first time, EPFL researchers have exclusively observed molecules participating in hydrogen bonds in liquid water, measuring electronic and nuclear quantum effects that were previously accessible only via theoretical…
A ‘new synthetic frontier’ for quantum dots
Replacing organic solvents with molten salt lets researchers grow “previously unimaginable nanocrystals”. The type of semiconductive nanocrystals known as quantum dots are both expanding the forefront of pure science and…