A logarithmic spiral with a diameter of 500 μm, approximately half the diameter of a sewing needle. Image Credit: Yilin Wong

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Health & Life

Life & Chemistry
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Chemistry and Force Create Stunning Spiral Patterns on Surfaces

Hundreds of regular patterns spontaneously form on a small germanium chip Key takeaways UCLA doctoral student Yilin Wong noticed that some tiny dots had appeared on one of her samples, which had been accidentally left out overnight. The layered sample consisted of a germanium wafer topped with evaporated metal films in contact with a drop of water. On a whim, she looked at the dots under a microscope and couldn’t believe her eyes. Beautiful spiral patterns had been etched into the…

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First-of-Its-Kind Medication Cuts Heart Attacks and Strokes
Health & Medicine

First-of-Its-Kind Medication Cuts Heart Attacks and Strokes

Sotagliflozin, a drug recently approved by the Food and Drug Administration to treat type 2 diabetes and kidney disease with additional cardiovascular risk factors, can significantly reduce heart attack and stroke among these patients, according to results from an international clinical trial led by a Mount Sinai researcher. Sotagliflozin is a sodium-glucose cotransporter (SGLT) inhibitor. It blocks the function of two proteins, known as SGLT1 and SGLT2, which move glucose and sodium across cell membranes and help control blood sugar…

A Dungeness crab (Metacarcinus magister) rests in the shadows near a rocky reef. Image Credit: Pat Webster @underwaterpat
Life & Chemistry

Marine Species Vulnerable to Climate Change, New Study Reveals

New paper clearly classifies most at-risk species to help California fisheries managers prioritize efforts  Dungeness crab, Pacific herring, and red abalone are among the marine species most vulnerable to the changing climate’s effect on California’s coastal waters, a new study led by UC Santa Cruz researchers finds. In a paper published on February 12 in the journal PLOS Climate, the team seeks to help the California Department of Fish and Wildlife (CDFW) in its efforts to develop and implement climate-ready…

Health & Medicine

Neural Mechanisms: Insights Into Overcoming Nicotine Withdrawal

Identification of the role of striatal cholinergic interneurons in nicotine withdrawal symptoms  According to the World Health Organization (WHO), over 22% of the global population smokes, with more than 9 million smoking-related deaths reported annually. Effective treatments to alleviate nicotine withdrawal symptoms caused by smoking cessation are essential for successful smoking cessation. Currently, approved treatments for nicotine withdrawal include Bupropion and Varenicline, but there is a pressing need for new therapeutic options to improve smoking cessation success rates. The research…

A microscope image of lung cancer cells (purple) containing the activated form of a metabolic enzyme called GUK1 (brown) that supports cancer growth. Image Credit: Image: Haigis lab
Health & Medicine

New Insights Uncover Lung Cancer’s Defensive Weaknesses

Scientists uncover an enzyme that boosts cancer cell metabolism to fuel growth  At a glance: Lung cancer is a particularly challenging form of cancer. It often strikes unexpectedly and aggressively with little warning, and it can shapeshift in unpredictable ways to evade treatment. While researchers have gleaned important insights into the basic biology of lung cancer, some of the disease’s molecular maneuvers have remained elusive. Now, a team led by scientists at Harvard Medical School has made strides in understanding…

A codon, a sequence of three nucleotides in DNA and RNA that codes for a specific amino acid, acts like an “instruction manual” for protein synthesis, telling the cell which of the 20 natural amino acids to add to a growing protein chain — or, in the case of the three “stop” codons (known as TAG, TGA, and TAA), signaling the termination of protein synthesis. Yale scientists recoded a cell to have a single, non-degenerative TAA codon. The newly “free” TGA and TAG codons have been reassigned to encode nonstandard amino acids into synthetic proteins that possess new chemistries with innumerable applications. Image Credit: Yale University / Michael S. Helfenbein
Medical Engineering

Yale Scientists Redefine Genome for Programmable Proteins

Synthetic biologists from Yale were able to re-write the genetic code of an organism — a novel genomically recoded organism (GRO) with one stop codon — using a cellular platform that they developed enabling the production of new classes of synthetic proteins. These synthetic proteins, researchers say, offer the promise of innumerable medical and industrial applications that can benefit society and human health. The creation of the landmark GRO, known as “Ochre” — which fully compresses redundant, or “degenerate” codons,…

Thomas Karikari, Ph.D. Image Credit: UPMC
Life & Chemistry

New Biomarker Test Detects Alzheimer’s Earlier, Pitt Study Finds

Years before tau tangles show up in brain scans of patients with Alzheimer’s disease, a biomarker test developed at the University of Pittsburgh School of Medicine can detect small amounts of the clumping-prone tau protein and its misfolded pathological forms that litter the brain, cerebrospinal fluid and potentially blood, new research published today in Nature Medicine suggests. The cerebrospinal fluid biomarker test correlates with the severity of cognitive decline, independent of other factors, including brain amyloid deposition, thereby opening doors…

Ältere asiatische Patientinnen und Krebsspezialisten treffen sich nach Vereinbarung, um Behandlungsempfehlungen zu erhalten – von nansanh, Envato.
Health & Medicine

Impact of Pain on Cancer Survivors’ Non-Opioid Use

U.S. data indicate that pain is linked with a greater likelihood of tobacco and cannabis use among cancer survivors. Experiencing pain may increase the odds that cancer survivors will use cigarettes and cannabis, according to a recent study published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society. The study also found that cigarette smoking and pain are linked to more treatment-related side effects and worse health among cancer survivors. Pain and use of cigarettes, e-cigarettes,…

Gas transport through a metal cluster-containing crystalline solid.Hydrogen and carbon monoxide travel at different speeds due to their molecular size relative to the size of nanoscale tunnels in the structure. While hydrogen binds reversibly, carbon monoxide binds irreversibly and distorts the original crown-motif of the platinum and gold atoms into a chalice-motif. Image Credit: Tokyo Metropolitan University
Life & Chemistry

Gas Adsorption Insights on Platinum and Gold Nanotunnels

Understanding gas diffusion in nanoscale voids key to new gas technologies  Tokyo, Japan – Researchers from Tokyo Metropolitan University have elucidated how hydrogen and carbon monoxide is adsorbed into solids containing a crown-motif structure of platinum and gold. Using quick-scan X-ray absorption measurements and theoretical calculations, they studied a solid of [PtAu8(PPh3)8]-H[PMo12O40] called PtAu8-PMo12 and found that gas adsorption is affected strongly by the dimension of nanoscale voids in the structure. This highlights the importance of engineering voids in materials…

EEG ad tDCS chould serve as the basis of therapeutic strategies to combat newrological disorders. Image Credit: Institute of Science Tokyo
Medical Engineering

Using Electroencephalography to Improve Language Disorder Treatments

Researchers work towards an inexpensive and portable solution for treating aphasia  Electroencephalography (EEG) may offer a more accessible alternative to functional magnetic resonance imaging (fMRI) for guiding transcranial direct current stimulation (tDCS) when treating aphasia. Researchers from Institute of Science Tokyo found an 80% agreement between EEG and fMRI in identifying brain regions activated during language tasks. Furthermore, EEG-guided tDCS improved picture-naming speed in participants, indicating its potential for innovative therapies in language disorders. Many neurological disorders are directly linked…

NEJM study finds patients with blockages in medium-sized vessels in the brain who had endovascular treatment did not do any better and did not see any improvement compared to patients who had the standard of care. Dr. Michael Hill, MD, Dr. Mayank Goyal, MD, PhD (right). Image Credit: Riley Brandt, University of Calgary
Health & Medicine

Best Approach for Stroke in Medium-Sized Blood Vessels Identified

Calgary’s Stroke Program advancing science to improve care, treatment and outcomes for patients  University of Calgary’s Hotchkiss Brain Institute researchers with the Calgary Stroke Program at Foothills Medical Centre revolutionized treatment for stroke with the ESCAPE Trial, proving that a clot retrieval procedure known as endovascular thrombectomy (EVT) can dramatically improve patient outcomes after an acute ischemic stroke caused by a blockage in a large-sized blood vessel. Building on that knowledge, the team launched the ESCAPE-MeVO clinical trial to assess…

DaeYong Lee (right), an assistant professor with Virginia Tech’s Fralin Biomedical Research Institute, blazes trails in under-explored areas of cancer therapy with (from left) postdoctoral associate EunHye Kim, research assistant Katelyn Wahl, and biomedical engineering graduate student Erica Guelfi. Image Credit: Clayton Metz/Virginia Tech
Health & Medicine

Innovative Biomaterials Transforming Cancer Treatments

Fralin Biomedical Research Institute cancer researchers examine how modifying the physical properties of biomaterials can improve immunotherapy for cancer treatment  Modifying the physical characteristics of microscopic biomaterials to interact seamlessly with the body’s tissues could unlock safer and more effective cancer treatments, according to Virginia Tech researchers at the Fralin Biomedical Research Institute at VTC. In an online review slated for the Feb. 10 issue of the Journal of Controlled Release, a research team led by DaeYong Lee, an assistant professor with…

Life & Chemistry

UC Davis Researchers Complete Total Synthesis of Ibogaine

Discovery creates opportunities to study therapeutic properties of ibogaine and related compounds  Ibogaine — a psychoactive plant derivative — has attracted attention for its anti-addictive and anti-depressant properties. But ibogaine is a finite resource, extracted from plants native to Africa like the iboga shrub (Tabernanthe iboga) and the small-fruited voacanga tree (Voacanga africana). Further, its use can lead to irregular heartbeats, introducing safety risks and an overall need to better understand how its molecular structure leads to its biological effects….

A new drug delivery system shows promise for treating a rare, aggressive form of cancer affecting pregnant women and new mothers. Oregon State's Olena Taratula and collaborators including OSU postdoctoral researcher Babak Mamnoon and Maureen Baldwin, a physician at Oregon Health & Science University, designed a type of drug nanocarrier known as a polymersome to specifically target a protein in choriocarcinoma cells. Depicted is a polymersome with its methotrexate cargo. Illustration by Parinaz Ghanbari. Image Credit: Parinaz Ghanbari
Health & Medicine

Improved Treatment Method for Rare Pregnancy-Related Cancer

PORTLAND, Ore. – A new drug delivery system shows promise for treating a rare, aggressive form of cancer affecting pregnant women and new mothers, and it has potential with other cancers as well. Scientists led by Olena Taratula, a nanomedicine researcher at Oregon State University, have found a way to better ensure the drug used to combat the disease reaches tumor cells without damaging healthy tissue. Findings of the study into choriocarcinoma, which occurs in the United States at a rate…

Cannabis warning sign. Image Credit: Journal of Studies on Alcohol and Drugs
Health & Medicine

Study Finds Warning Signs Ineffective Against Cannabis Use in Pregnancy

Warning signs at dispensaries about the potential health effects of cannabis use in pregnancy may not be effective, according to a new report in the Journal of Studies on Alcohol and Drugs, based at Rutgers University. In fact, those who are pregnant and using cannabis may actually distrust the content of warning signs altogether. “Mandatory warning signs aren’t working,” says lead researcher Sarah C. M. Roberts, DrPH, of the University of California, San Francisco. In fact, some of the respondents…

The female receives a dead insect as a gift from the male during mating. The gift provides the female with the necessary protein to produce eggs. If the male arrives empty-handed, he is rejected. Image Credit: Tom Houslay
Life & Chemistry

Male Flies Sharpen Eyesight to Outwit Females

With bloated bellies and hairy legs, female flies try to look bigger to get food from courting mates. But male flies, in turn, have sharpened their eyesight to call their bluff. A new study by researchers from the Universities of Gothenburg and Stockholm suggests that this is an ongoing evolution where both sexes try to outsmart each other. For the first time, researchers have been able to show that also males can develop traits that help them pass on their…

Schematic model depicting single molecule DNA translocating through a nanoprecipitated nanopore. Image Credit: Makusu Tsutsui
Life & Chemistry

Electrical Control of Nanopore Diameter: Shut the Nano Gate!

Researchers from SANKEN (The Institute of Scientific and Industrial Research), at Osaka University develop a versatile electrically controlled nanogate that can be tailored for specific molecules  A gate that can be open or shut to allow or block the passing of species on one or both sides applies not only on the macroscale, for example a farm gate used to control stock movement, but also at the nanoscale, where a gate can control the translocation of single molecules. A collaboration…

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