How blue-green algae manipulate microorganisms

Cyanobacteria in high-density-cultures
(c) Alexander Kraus/Universität Freiburg

Research team at the University of Freiburg discovers previously unknown gene that indirectly promotes photosynthesis.

Cyanobacteria – also called blue-green algae – are known as the “plants of the ocean” because they carry out photosynthesis on a gigantic scale, produce oxygen and extract the greenhouse gas CO2 from the environment. However, to do this they need additional nutrients such as nitrogen. A team headed by biologist Prof. Dr Wolfgang R. Hess, Professor of Genetics at the University of Freiburg, has discovered a previously unknown gene that plays a key role in the coordination of the nitrogen and carbohydrate metabolism: with it, cyanobacteria indirectly regulate the growth of microorganisms that promote photosynthesis. “Our work shows that there are numerous previously unknown interdependencies even between the smallest organisms in the environment and that many previously unknown genes play a part in this,” says Hess. The results have been published in the science journal Nature Communications.

Balance between primary nutrients

The amounts of carbon (CO2) and nitrogen available for plants, algae and cyanobacteria are not always the same. For photosynthesis, a physiologically relevant balance between these two primary nutrients is of huge importance. In the genetic data of cyanobacteria, Alexander Kraus, doctoral student with Wolfgang R. Hess at the University of Freiburg, has now discovered and characterised a gene that plays a key part in this context: the gene encodes a protein named NirP1. This is only produced if the cells identify a deficiency of carbon in relation to the available nitrogen.

The protein is itself too small to act as an enzyme like many other proteins. Working with Dr Philipp Spät and Prof. Dr Boris Maček from the Proteome Center at the University of Tübingen, the researchers were however able to discover that NirP1 can bond permanently with an enzyme that would normally convert nitrite into ammonium. NirP1 prevents this and thus ensures that nitrite accumulates in the cells; this is then followed by further massive metabolic changes, which were analysed in detail in collaboration with Prof. Dr Martin Hagemann ‘s team at the University of Rostock. Finally, the cyanobacteria begin to export nitrite to the environment, where the additional nitrite stimulates the growth of useful microorganisms, and so a microbiome that is beneficial to the photosynthesis of the cyanobacteria.

Ideas for further research

The results suggest ideas for ongoing research into the interactions between microorganisms and the role of this regulating gene which was previously little known, says Hess. “In addition, small protein regulators like NirP1 could in future be deployed in ‘green’ and ‘blue’ biotechnology for targeted control of the metabolism.”

Summary:

Original publication: Kraus, A., Spät, P., Timm, S., Wilson, A., Schumann, R., Hagemann, M., Maček, B., Hess, W. R.: Protein NirP1 regulates nitrite reductase and nitrite excretion in cyanobacteria. In: Nature Communications 15, 1911 (2024).
DOI: https://doi.org/10.1038/s41467-024-46253-4

Prof. Dr Wolfgang R. Hess is Professor of Genetics at the Faculty of Biology of the University of Freiburg. His research focuses include RNA biology with the use of experimental and bioinformatic methods, microbial system biology and the biology of native CRISPR systems and their application. Alexander Kraus is a doctoral student at the University of Freiburg.

The discovery was made with input from a network of researchers involving the universities of Freiburg, Tübingen and Rostock. The work was funded by the German Research Foundation (DFG) as part of the SCyCode project.

Contact:
University and Science Communications
University of Freiburg
Tel.: +49 761 203 4302
email: kommunikation@zv.uni-freiburg.de

https://www.kommunikation.uni-freiburg.de/pm-en/press-releases-2024/how-blue-green-algae-manipulate-microorganisms?set_language=en

Media Contact

Rimma Gerenstein Hochschul- und Wissenschaftskommunikation
Albert-Ludwigs-Universität Freiburg im Breisgau

All latest news from the category: Life Sciences and Chemistry

Articles and reports from the Life Sciences and chemistry area deal with applied and basic research into modern biology, chemistry and human medicine.

Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.

Back to home

Comments (0)

Write a comment

Newest articles

Innovative 3D printed scaffolds offer new hope for bone healing

Researchers at the Institute for Bioengineering of Catalonia have developed novel 3D printed PLA-CaP scaffolds that promote blood vessel formation, ensuring better healing and regeneration of bone tissue. Bone is…

The surprising role of gut infection in Alzheimer’s disease

ASU- and Banner Alzheimer’s Institute-led study implicates link between a common virus and the disease, which travels from the gut to the brain and may be a target for antiviral…

Molecular gardening: New enzymes discovered for protein modification pruning

How deubiquitinases USP53 and USP54 cleave long polyubiquitin chains and how the former is linked to liver disease in children. Deubiquitinases (DUBs) are enzymes used by cells to trim protein…