How to shift gears in a molecular motor

Researchers at Linköping University have developed a design principle for how to transfer the rotary motion to another part of a molecular system and have complete control over the direction of rotation.
Credit: Thor Balkhed/Linköping University

“Artificial molecular motors are molecules that absorb light from an external source, such as sunlight, and convert the energy in light into kinetic energy,” says Bo Durbeej, professor at Linköping University (LiU), who led the study published in Chemistry – a European Journal.

“Molecular motors” may sound like science fiction, but in the body there are many biological molecular motors that drive muscles and transport substances inside cells. Chemistry and nanotechnology researchers have long been aiming to develop artificial molecular motors, which may be useful in several areas in the future. Possible applications include using them to deliver medical drugs to the right place in the body or for storing solar energy.

But a motor on its own is not enough. A car having only a motor or an engine but no wheels would not get far. The power from the motor must be transferred – to the wheels, in the case of the car – and this is done via a gearbox. Similarly, the next step in this research field is to construct molecular gears that can transfer the kinetic energy from one part of a molecule to another. Future applications depend on being able to use the motion somewhere else than where it was created.

“Many scientists have long tried to construct molecular gears. We have developed a design principle for how to transfer the rotary motion to another part of a molecular system and have complete control over the direction of rotation. Previous designs have not been able to control the rotary motion,” says Bo Durbeej.

A major challenge with developing a molecular photogear is that the part that you want to rotate, the “propeller”, is attached to the rest of the molecule by a single bond. Single bonds rotate very easily, making it difficult to control directionality. But the LiU researchers have now succeeded in solving this problem by finding a good combination of several factors, including the distance between the propeller and the part of the molecule that constitutes the “motor” itself.

The researchers have confirmed that their design works, by doing calculations and advanced computer simulations on supercomputers at the National Supercomputer Centre in Linköping provided by the Swedish National Infrastructure for Computing, SNIC, and the National Academic Infrastructure for Supercomputing in Sweden, NAISS.

“We’ve now shown that our design principle works. The next step is to develop molecular photogears that are as easy as possible to synthesise,” says Bo Durbeej.

The study was carried out with support from the Swedish Research Council, the Olle Engkvist Foundation and the Carl Trygger Foundation for Scientific Research.

Article: A Proof-of-Principle Design for Through-Space Transmission of Unidirectional Rotary Motion by Molecular Photogears, Enrique Arpa, Sven Stafström and Bo Durbeej, (2023), Chemistry – A European Journal, published online 31 October 2023, doi: 10.1002/chem.202303191

See also journal cover: https://doi.org/10.1002/chem.202304046

Journal: Chemistry – A European Journal
DOI: 10.1002/chem.202303191
Method of Research: Computational simulation/modeling
Subject of Research: Not applicable
Article Title: A Proof-of-Principle Design for Through-Space Transmission of Unidirectional Rotary Motion by Molecular Photogears
Article Publication Date: 31-Oct-2023
COI Statement: The authors declare no conflict of interest.

Media Contact

Karin Söderlund Leifler
Linköping University
karin.soderlund.leifler@liu.se
Office: 461-328-1395

Expert Contact

Bo Durbeej
Linköping University
bo.durbeej@liu.se
Office: +46 13 28 24 97
Cell: +46 70 085 05 56
 @liu_universitet

Media Contact

Karin Söderlund Leifler
Linköping University

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