Life Sciences and Chemistry

Researchers at The University of Texas M. D. Anderson Cancer Center have figured out a key molecular step by which a cancer cell can unhook itself from the mesh weave of other cancer cells in a tumor, and move away to a different part of the body – the process, known as metastasis, that makes cancer so dangerous.

Describing what they call a critical “molecular switch” – detailed in the advance online edition of the journal Nature Cell Biology – the researchers say the door is now

Animal study sheds light on effects of hospital drugs

Chronic use of opiate drugs may alter brain neurons to make animal brains more sensitive to stress, according to a new study. If the research proves applicable to humans, the findings may help explain how hospital patients who have received morphine may be susceptible to stress disorder, attention problems and sleep disturbances. The effects on the brain may also contribute to better understanding of drug addiction.

The

Cannabinoid receptor necessary, but can’t be overloaded, mouse model shows

Marijuana use may increase the risk of ectopic (tubal) pregnancies, researchers at Vanderbilt University Medical Center reported this week. The researchers studied CB1, a “cannabinoid” receptor that binds the main active chemical for marijuana, delta-9-tetrahydrocannabinol (THC).

In pregnant mice that lacked the gene for the receptor, or in which the receptor was blocked, the embryo failed to go

In what may be a first step toward expanding the arsenal against HIV, UC Irvine researchers have successfully targeted an HIV protein that has eluded existing therapies.

Researchers targeted Nef, a protein responsible for accelerating the development of acquired immunodeficiency syndrome, or AIDS. Nef was targeted with small molecules synthesized by the researchers – molecules that disrupted Nef’s interaction with other proteins. The technique used for identifying the synthetic mo

Stem cells taken from umbilical cord blood, then given intravenously along with a drug known to temporarily breach the brain’s protective barrier, can dramatically reduce stroke size and damage, Medical College of Georgia and University of South Florida researchers say.

“What we found was interesting, phenomenal really,” says Dr. Cesario V. Borlongan, neuroscientist and lead author of the study published in the October issue of the American Heart Association journal, Stroke.

Implications include developing materials that both detect and kill biological agents

University of Pittsburgh researchers have synthesized a simple molecule that not only produces perfectly uniform, self-assembled nanotubes but creates what they report as the first “nanocarpet,” whereby these nanotubes organize themselves into an expanse of upright clusters that when magnified a million times resemble the fibers of a shag rug. Moreover, unlike other nanotube structures, these tubes