Life Sciences and Chemistry

New technique, partial shotgun-genome sequencing at 1.5X coverage of genome, provides a useful, cost-effective way to increase number of large genomes analyzed

Analysis reveals that 650 million base pairs of DNA are shared between dog and humans including fragments of putative orthologs for 18,473 of 24,567 annotated human genes; Data provide necessary tools for identifying many human and dog disease genes

Researchers at The Institute for Genomic Research (TIGR) and The Cent

Graduate student camped out in the lab, sleepless in Seattle, to collect the data

Scientists at Fred Hutchinson Cancer Research Center have made a landmark discovery in yeast that may hold the key to revealing why growing older is the greatest cancer-risk factor in humans. Their findings appear in the Sept. 26 issue of Science.

Senior author Daniel Gottschling, Ph.D., a member of Fred Hutchinson’s Basic Sciences Division, and first author Michael McMurray, a graduate stu

A protein in Salmonella bacteria called SipA invades healthy human cells by using two arms in a “stapling” action, according to scientists at the University of Virginia Health System. The U.Va. researchers, working with colleagues at Rockefeller University in New York, report their findings in the September 26 edition of the magazine Science.
Edward Egelman, professor of biochemistry and molecular genetics at U.Va., said the significance of this research is that it could be possible to design mol

Resistance exercise may directly reset the body clocks in skeletal muscle, according to research published in Genome Biology this week. This result may partly explain how exercising early in the day helps jet-lagged bodies readjust to their new time zone.

Many processes in the body vary in a 24-hour rhythm called the circadian rhythm. These rhythms are controlled by molecular clocks, in organs such as the liver, in tissues such as skeletal muscle, and in the hypothalamus, a part of the brai

MRC geneservice announced today [24th September, 2003] the availability in the UK of a major new tool which will revolutionise proteomics, and hasten the characterisation of the proteins coded by each gene. Dr Marc Vidal and his team at the Dana-Farber Cancer Institute in Boston, USA have produced clones from Open Reading Frames (ORFs) of genes – protein-encoding nucleotide sequences – from the model organism Caenorhabditis elegans. Whilst much is known about the sequence of genes, understanding what

For those who delight in eating Mediterranean anchovies, the taste of inshore varieties has long been preferred to that of the open-sea kind. An IRD researcher has shown that this organoleptic difference coincides with a real biological distinction. In the Mediterranean Sea there is not just one species of European anchovy but two, each occupying its own habitat.

Correspondence analysis was performed of all existing genetic data obtained between 1980 and 1996 concerning anchovies from the M