Life Sciences and Chemistry

The human body has barriers such as skin and the lining of airways and gut that protect and separate us from the outside world. If these barriers are breached, our survival is threatened. Therefore it is critical that the cells that form these barriers have mechanisms that can instantly repair any injury.

University of Iowa researchers have discovered a surprisingly simple but effective repair system in airway barrier cells. The UI study shows that by placing a messenger molecule on one side

New research shows that a more effective method of genetic engineering could be used to eradicate or manipulate entire, wild populations of harmful species rather than simply small, managed populations, as is currently the case. The research,* to be published in Proceedings B, a learned journal produced by the Royal Society, shows in computer simulations how a single, ’selfish’ gene could be used to infect the host and eliminate ’problem’ genes, for example a gene allowing mosquit

Discovery points to one possible path to novel drug development for cancer, AIDS, some inflammation

Using a new approach, Mayo Clinic researchers have successfully “taught” an RNA molecule inside a living cell to work as a decoy to divert the actions of the protein NF-kappaB, which scientists believe promotes disease development. The findings are published in the current issue of Proceedings of the National Academy of Sciences.

Although it also plays helpful roles in the bod

Johns Hopkins scientists have discovered that primitive human embryonic stem (ES) cells, temperamental in the lab, can be grown with the help of special cells from bone marrow, offering an easily obtained and well-studied source of human cells to nurture the human ES cells as they divide.

First announced in 1998, human embryonic stem cells are usually grown in the lab on a “feeder layer” of mouse cells. Feeder cells send as yet unknown signals to the primitive human ES cells, preventing the

The popular stimulant blocks adenosine receptors, and is the most likely mechanism of central nervous actions that delay exercise-related fatigue, a new study finds

Consuming caffeine, whether in coffee of soft drinks, has been shown to delay fatigue during prolonged exercise. Studies have shown, for example, that ingesting three to nine mg/kg of caffeine can increase the amount of exercise time to achieve by as much as 50 percent. How caffeine achieves this effect has not been ful

Proteins, it appears, have taken Frank Sinatra’s “I Did It My Way” close to heart. A new study published in the current issue of Proceedings of the National Academy of Sciences (PNAS) reveals how single proteins, each a few nanometers (billionths of a meter) long, fold to assume their final shape. It shows that even proteins having the same final shape achieve it by taking different routes.

Proteins are the fundamental components of all living cells. They start out as randomly shaped c