Scientists in hot pursuit of first new drug for global killer in 50 years

Dr Nick West, Associate Faculty of the Mycobacterial group at Centenary, is looking at the genetics of TB in the hope they will reveal a way to reduce the impact of one of the deadliest diseases in the world.

Dr West, explains, “When someone is infected with TB they either become sick immediately or the disease stays inactive, latent.”

“Unfortunately, the antibiotics we use to fight TB aren't effective against latent TB and can only be used when the disease becomes active. This is a major problem as 1 out of 10 people who have latent TB will develop the active disease, becoming sick and contagious.”

Dr West and his team have made a vital discovery in the development of a new drug that could cure TB in the latent stage. If the project succeeds, it will be the first new treatment for TB since 1962.

This is exciting news given that TB kills almost 2 million people each year. One third of the world's population, or two billion people, are infected with TB. Every second of every day another person is infected.

And worse, TB is at Australia's doorstep with the fastest growing incidence of the disease occurring in South East Asia. Luckily, the Centenary Institute, Australasia's largest TB research facility, is mounting a winning fight against this global killer.

Dr West explains, “We have investigated a protein that is essential for TB to survive and we have had some success in developing a drug that will inhibit this protein. Our goal over the coming months is to find out the full extent of this drug's potential.”

“If we can figure out a way to treat TB when it's in a latent stage, then we could save millions of lives throughout the world.”

Media contact

For more information or to arrange an interview with a scientist contact:
LauraBeth Albanese, Marketing Coordinator, the Centenary Institute
p: 02 9565 6118 m: 0431 029 215 e: l.albanese@centenary.org.au
Notes to Editor:
About the Centenary Institute
The Centenary Institute is an independent medical research institute, affiliated with Royal Prince Alfred Hospital and the University of Sydney. Our unique blend of highly skilled staff and state-of-the art equipment and facilities has allowed us to become world leaders in three critical areas of medical research – cancer, cardiovascular disease and infectious diseases.