Ingestible microbiome sampling pill technology advances
The pill devices have a soft elastic exterior with sidewall inlets, which are triggered to open by pH levels in the small intestine environment. Elastic microvalves close the inlets once the intestinal microbiome content has been collected.
Credit: Sameer Sonkusale, Tufts University Nano Lab
Precision measurement of intestinal microbiome taking steps toward human clinical trials.
Significant progress has been made at Tufts University School of Engineering in the development of a small device, about the size of a vitamin pill, that can be swallowed and passed through the gastrointestinal tract to sample the full inventory of microorganisms in an individual’s gastro-intestinal tract. This device has the potential to advance research on the relationship between resident bacteria and a wide range of health conditions. It could also serve as a diagnostic tool for adjusting the microbiome or administering drugs to treat those conditions.
The device has completed preclinical characterization – as presented in the journal Device – paving the way for upcoming human clinical trials. It is characterized by a 3D printed soft elastic exterior with sidewall inlets that open in response to the changing acidity as the pill reaches the small intestine. The pill uses elastic microvalves with swellable polyacrylate beads that close the inlets once intestinal content has been collected. The technology was developed at Tufts Nano Lab by a team led by Professor Sameer Sonkusale, along with post-doctoral researcher Ruben Del-Rio-Ruiz who is lead author on the preclinical study. A second team of researchers led by Professor Giovanni Widmer at the Cummings School of Veterinary Medicine at Tufts University assisted by PhD candidate Debora Silva, performed the tests in animals and analyzed the samples collected by the pill.
Improvements over previous versions of the pill include using a soft elastic exterior rather than a rigid shell, to make it easier to ingest, and significantly improved control over localized sampling of the microbiome in the small intestine.
Current techniques to study the intestinal microbiome primarily rely on fecal matter. This technology represents a significant advance in understanding the function of the thousands of microbial species populating the entire length of the gastrointestinal tract and their effects on health.
Journal: Device
DOI: 10.1016/j.device.2024.100406
Method of Research: Experimental study
Subject of Research: Animals
Article Title: Soft Autonomous Ingestible Device for Sampling the Small Intestinal Microbiome
Article Publication Date: 12-Jun-2024
COI Statement: Authors declare no conflicts of interest
Media Contact
Mike Silver
Tufts University
mike.silver@tufts.edu
Office: 6176270545
All latest news from the category: Medical Engineering
The development of medical equipment, products and technical procedures is characterized by high research and development costs in a variety of fields related to the study of human medicine.
innovations-report provides informative and stimulating reports and articles on topics ranging from imaging processes, cell and tissue techniques, optical techniques, implants, orthopedic aids, clinical and medical office equipment, dialysis systems and x-ray/radiation monitoring devices to endoscopy, ultrasound, surgical techniques, and dental materials.
Newest articles
First-of-its-kind study uses remote sensing to monitor plastic debris in rivers and lakes
Remote sensing creates a cost-effective solution to monitoring plastic pollution. A first-of-its-kind study from researchers at the University of Minnesota Twin Cities shows how remote sensing can help monitor and…
Laser-based artificial neuron mimics nerve cell functions at lightning speed
With a processing speed a billion times faster than nature, chip-based laser neuron could help advance AI tasks such as pattern recognition and sequence prediction. Researchers have developed a laser-based…
Optimising the processing of plastic waste
Just one look in the yellow bin reveals a colourful jumble of different types of plastic. However, the purer and more uniform plastic waste is, the easier it is to…