Researchers unveil a real-time MRI method for the early detection of stroke
An international research group at the Max Planck Institute for Biological Cybernetics developed a brain imaging method for improved and early assessment of stroke.
Now published in PNAS, their study presents a methodology which monitors calcium ion fluctuations in the brain using a molecular functional MRI approach.
The researchers reported observations from high-resolution imaging of the changing amount of calcium in the brain tissue during stroke. Their reported novel method shows precisely the onset and course of ischemic stroke, the severity of which can be investigated by a three-dimensional MR image reconstruction.
Specifically, they used a calcium-sensitive contrast agent as a biomarker, which enabled the changes in calcium concentration to be traced and thus correlated with the spatiotemporal dynamics of cerebral ischemia.
“The commonly used imaging techniques for ischemia diagnosis, such as ultrasonography or computed tomography, often lack the necessary sensitivity to detect ischemia at an early stage,” comments Goran Angelovski, the principal investigator of this study.
“We consider our method an important step forward in developing reliable and precise neuroimaging techniques for non-invasive investigations of brain function and dysfunction. It is highly specific for calcium, a messenger of various cellular signals, allowing better differentiation of damaged regions at an early stage of brain injury.”
Cerebral ischemia is characterized in conditions of a reduced blood supply to the brain tissue, causing a deprivation of oxygen and glucose delivery and a production failure of adenosine triphosphate (ATP), a key energy carrier. The resulting energy crisis can trigger a cascade of detrimental biochemical and physiological events, consequently leading to acute or delayed cell death.
Revealing immediate changes during reperfusion are essential for the appropriate treatment and subsequent recovery of brain tissues.
Given that the physiological changes in damaged brain tissue occur rather fast, the method may prove ideal for the prompt detection of ischemic onset, and can offer substantial insights into the neurobiology of various neurological disorders.
Priv.-Doz. Dr. Goran Angelovski
+49 7071 601 916
goran.angelovski@tuebingen.mpg.de
www.pnas.org/cgi/doi/10.1073/pnas.1908503116
Media Contact
More Information:
http://kyb.mpg.deAll latest news from the category: Medical Engineering
The development of medical equipment, products and technical procedures is characterized by high research and development costs in a variety of fields related to the study of human medicine.
innovations-report provides informative and stimulating reports and articles on topics ranging from imaging processes, cell and tissue techniques, optical techniques, implants, orthopedic aids, clinical and medical office equipment, dialysis systems and x-ray/radiation monitoring devices to endoscopy, ultrasound, surgical techniques, and dental materials.
Newest articles
Reconstructing plesiosaur swimming styles with bio-mimetic control
A research group may have unraveled the mystery behind the locomotion of the ancient marine reptile, the plesiosaur, by recreating a bio-inspired control system that accounts for motion adjustment. Extinct…
Kagome breaks the rules at record breaking temperatures
In case you’re scratching your head, we help break it down. Using muon spin rotation at the Swiss Muon Source SmS, researchers at PSI have discovered that a quantum phenomenon…
New findings on heart failure
Dysferlin protein protects and shapes the membrane of heart muscle cells. Researchers from the Heart Center of the University Medical Center Göttingen (UMG) led by Priv.-Doz. Dr Sören Brandenburg have…