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The same characteristics that make misfolded proteins known as prions such a pernicious medical threat in neurodegenerative diseases may offer a construction toolkit for manufacturing nanoscale electrical circuits, researchers report this week in the online edition of the Proceedings of the National Academy of Sciences.
Scientists working at Whitehead Institute for Biomedical Research and the University of Chicago write that they have used the durable, self-assembling fibers formed by prions as
A protein responsible for the assembly of cell cilia – the hair-like projections from cells – may cause polycystic kidney disease, the most common genetic cause of kidney failure, according to a new study at UT Southwestern Medical Center at Dallas.
The study, which will be published online this week and will appear in a future edition of the Proceedings of the National Academy of Sciences, is the first to directly test the role of cilia in polycystic kidney disease. Previous studies have h
EMBL researchers discover a mechanism by which cells monitor estrogen
The hormone estrogen is recognized by most people because of its important role in women’s reproductive cycles. It also has other functions in the body: it drives some types of cells to replicate themselves, and it has been linked to the development of tumors. Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg have now described a new model of how cells constantly monitor their exposur
Just as vegetables are essential to balancing the human diet, the inclusion of vegetation may be equally essential to balancing Earth’s climate models.
Scientists at MIT who were trying to create accurate models of climate change in the southern portion of the Sahara desert found that including a realistic component of vegetation growth and decay was absolutely essential. Without including the vegetation as a variable (rather than a fixed parameter), the models were not able to show the regi
In a new study published in the April 1, 2003 issue of Genes and Development, scientists at University Health Network’s Advanced Medical Discovery Institute (AMDI)/Ontario Cancer Institute (OCI) have shown that a molecule called caspase-8 plays a key role in the immune system response, by controlling how T-cells are activated to respond to infections.
T-cells are white blood cells that recognize and fight off viruses and bacteria. When T-cells encounter these foreign invaders they build up
A new three-drug cocktail used to treat ALS, or Lou Gehrig’s Disease, may increase life span and decrease disease progression according to a study conducted at the Research Institute of the McGill University Health Centre (MUHC). The study, published in today’s issue of Annals of Neurology, is the first to look at this drug combination in a mouse model of ALS. This research was made possible by a partnership led by the Canadian Institutes of Health Research (CIHR), in conjunction with the A