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ACE inhibitor drug reduces heart failure in high-risk patients

The drug ramipril significantly reduced the onset of debilitating and often-fatal heart failure in a large group of high-risk patients, researchers report in today’s rapid access issue of Circulation: Journal of the American Heart Association.

Ramipril, trade-named Altace, is one of a family of high blood pressure medications known as ACE inhibitors. The drugs reduce the risk of death from heart failure – the inability of a weakened or damaged heart to pump enough blood through the body

Variety of casual acquaintances affects success and health

Knowing many kinds of people in many social contexts improves one’s chance of getting a good job, developing a range of cultural interests, feeling in control of one’s life and feeling healthy. Many know how important networking is, says researcher Bonnie Erickson, but the critical matter is the variety of acquaintances and not the mere number.

Erickson, Professor of Sociology at the University of Toronto, presents her research in an article, “Social Networks: The Value of Variety,” in the

Scientists find ’stem cells’ in human breast cancer

Discovery could explain current treatment failures and lead to more effective therapies for many cancers

Of all the neoplastic cells in human breast cancers, only a small minority – perhaps as few as one in 100 – appear to be capable of forming new malignant tumors, according to just-published research by scientists in the University of Michigan Comprehensive Cancer Center. The discovery could help researchers zero in on the most dangerous cancer cells to develop new, more effective t

Argonne researchers create powerful stem cells from blood

May revolutionize medical research and transplantation

The particularly powerful – and very scarce – flexible forms of stem cells needed for medical research and treatment may now be both plentiful and simple to produce, with a new technology developed at the U.S. Department of Energy’s Argonne National Laboratory – and the source is as close as your own bloodstream.

These flexible stem cells, able to morph into a variety of cell types, are called “pluripotent,” and before th

Teasing apart the molecules of life

Researchers devise new technique and measure the forces required to unzip DNA

Fifty years after James Watson and Francis Crick’s publication of the structure of DNA, research in the latest issue of the Journal of Biology shows how scientists can now measure the forces needed to tear the DNA double helix apart. The work was carried out using the first successful simultaneous combination of two important techniques for looking at single molecules – single molecule fluorescence and

Study may help explain sunlight’s role in melanoma development, have screening implications

A strong link exists between lifetime exposure to ultraviolet light, particularly lifetime sunburns, and the development of melanoma – the most lethal form of skin cancer.

Now, for the first time, scientists have identified a specific molecular pathway within cells that becomes mutated by ultraviolet light exposure, thereby speeding up melanoma development.

New findings published in the Feb. 4 issue of Proceedings of the National Academy of Sciences may have implications fo

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