A group of researchers led by the University of Colorado at Boulder have solved the crystal structure of a molecule switch that can trigger heart disease and cancer, paving the way for future drug designs to mitigate these diseases.

The key component of the switch is a protein called MEF2 that binds to the DNA and is involved in muscle cell, T cell and nerve cell development. In cases involving human hearts, it can lower gene activity that causes enlarged hearts, known as hypertrophic cardi

A new study suggests that lead may be harmful even at very low blood concentrations. The study, funded by the National Institute of Environmental Health Sciences of the National Institutes of Health, will appear in the April 17 edition of The New England Journal of Medicine.

The five-year study found that children who have blood lead concentration lower than 10 micrograms per deciliter suffer intellectual impairment from the exposure. The researchers also discovered that the amount of impai

The bizarre hydrothermal vent field discovered a little more than two years ago surprised scientists not only with vents that are the tallest ever seen – the one that’s 18 stories dwarfs most vents at other sites by at least 100 feet – but also because the fluids forming these vents are heated by seawater reacting with million-year-old mantle rocks, not by young volcanism.

The remarkable Lost City hydrothermal vent field, so named partly because it sits on a seafloor mountain named the

Virtual shapes created on a computer screen by manipulating ShapeTape, a flexible tape-like tool

U of T researchers have created software that will enable users to twist, bend, push and pull shapes in two and three dimensions.”

Our work represents a completely different way of interacting with computers,” says Professor Ravin Balakrishnan of U of T’s Department of Computer Science, who led the research. “It moves away from the ’one-size-fits-all’ keyboard and

An ultrathin film containing 1-nanometer thick clay particles has been created for the first time, an accomplishment that may yield new materials and devices for medicine, electronics and engineering, according to Purdue University and Belgian scientists.

Using a method that captures clay particles on a crystal, Purdue and Katholieke Universiteit Leuven research partners were able to produce, see and manipulate a single layer of clay. It would take 70,000 of these layers to equal the thickn

In a serendipitous spin-off of HIV/AIDS research, scientists at the National Institute of Allergy and Infectious Diseases (NIAID) and colleagues have found strong evidence that a genetic variation affecting immune system cells protects against heart disease. Details of the work, which also provides further evidence for the role of inflammation in heart disease, will appear in the April 15 issue of the Journal of Clinical Investigation.

“This work demonstrates how NIAID’s commitment to