Tamoxifen appears to reduce the risk of benign breast disease and may result in fewer biopsies, according to an analysis of data from a major randomized clinical trial of tamoxifen. The findings appear in the February 19 issue of the Journal of the National Cancer Institute.

Tamoxifen was shown in the Breast Cancer Prevention Trial to reduce the incidence of invasive and noninvasive breast cancer by as much as 50% compared to placebo. Other studies have suggested that tamoxifen can also dec

In the years after the American Revolution, U.S. presidents were talking about the British a lot, and then about militias, France and Spain. In the mid-19th century, words like “emancipation,” “slaves” and “rebellion” popped up in their speeches. In the early 20th century, presidents started using a lot of business-expansion words, soon to be replaced by “depression.”

A couple of decades later they spoke of atoms and communism. By the 1990s, buzzwords prevailed.

Jon Kleinberg, a p

We all know people who can take pain or stress much better than we can, and others who cry out at the merest pinprick. We’ve heard stories of people who did heroic deeds despite horrible injuries, and stereotypes about women’s supposedly sensitivity to pain that don’t mesh with their ability to withstand childbirth’s pain.

But what accounts for all these differences in how individuals feel and respond to pain? And why are some people, especially women, more frequently pr

Animals in the oceans surrounding Antarctica are under increasing threat. Fishery management organisations and governments need to do more to eliminate illegal fishing and regulate better legal fishing in Southern Ocean and adjacent areas according to Professor John Croxall speaking today (17 Feb) at a special symposium – Conserving Migratory Marine Organisms: Protecting animals with ocean-sized habitats organised by the American Association for the Advancement of Science (AAAS).

Charismatic

A cell type with the potential for making the four major types of human tissue has been found in the stomach and small intestine by a Medical College of Georgia researcher.

These VENT cells have been found in addition to the three sources of cells typically associated with gastrointestinal development, says Dr. Paul Sohal, MCG developmental biologist, who first identified these cells nearly a decade ago.

Identification of VENT – ventrally emigrating neural tube – cells within the

Researchers at the University of Pittsburgh Cancer Institute (UPCI), in collaboration with Johns Hopkins University School of Medicine have found that a recently discovered gene plays an essential role in mediating apoptosis, or cell death, in colorectal cancer cells. The results are published in the Feb. 18 issue of Proceedings of the National Academy of Sciences.

The gene, PUMA, or p53 up-regulated modulator of apoptosis, is controlled by p53 – a tumor-suppressing gene that prevents norma