Wie am 19 Oktober 2002 den Delegierten bei dem Kongress der European Society for Medical Oncology in Nizza mitgeteilt wurde, dürfte sich die Chip Technology zur Auswertung von genetischen Informationen in der Zukunft als eines der wichtigsten Instrumente für die Krebsprognose herausstellen.

Krebs wird durch Veränderungen oder Mutationen in Genen und durch andere Zellanomalien ausgelöst. Die Informationen des Human Genome Project bieten jetzt ein wertvolles Werkzeug, um die genetische Basis

Early results of North American trials of chemotherapy drug oxaliplatin

For patients with bowel cancer that has spread to other organs despite treatment there has been little hope until now. However, early results of trials in North America of a chemotherapy drug called oxaliplatin, given in conjunction with two standard drugs, 5-FU and leucovorin, delay tumour progression by 70% compared with the control component of the study. There is also a significant improvement in the symptoms

Laws that favor the use of diesel, rather than gasoline, engines in cars may actually encourage global warming, according to a new study. Although diesel cars obtain 25 to 35 percent better mileage and emit less carbon dioxide than similar gasoline cars, they can emit 25 to 400 times more mass of particulate black carbon and associated organic matter (“soot”) per kilometer [mile]. The warming due to soot may more than offset the cooling due to reduced carbon dioxide emissions over several decades, ac

Work stress is associated with a doubling of the risk of death from heart disease, finds a study in this week’s BMJ.

Researchers followed 812 healthy employees (545 men, 267 women) of a company in Finland for an average of 25 years. They gathered data on stress, blood pressure, cholesterol levels, and body mass index by questionnaire, interviews, and clinical examinations. Cardiovascular deaths were calculated using the national mortality register.

They found that job strain (high w

Two population studies in this week’s issue of THE LANCET highlight how poor air quality is directly related to increased risk of death from respiratory and cardiovascular disease.

Luke Clancy from St James Hospital, Dublin, and colleagues from Trinity College and Dublin Institute of Technology, Dublin, Ireland, and Harvard School of Public Health, Boston, USA, examined the effect of the 1990 coal ban in Dublin on population death-rates in the six years before and after the ban was i

Scientists from the McKusick-Nathans Institute for Genetic Medicine at Johns Hopkins may have discovered why a rare genetic disease is more common in children born to older fathers. The disease, Apert syndrome, leads to webbed fingers and early fusion of the skull bones and must be corrected by surgery.

While Apert syndrome itself affects only 1 in 160,000 births, the scientists believe their findings could extend to many of the 20 or so other genetic conditions similarly linked to older fa