The first clinical trial to compare directly two of the most widely-used drugs in advanced lung cancer, cisplatinin and carboplatin (both in combination with paclitaxel) – have concluded that the older drug, cisplatin, is the better treatment.
Patients given cisplatin and paclitaxel had better survival rates and their quality of life was just as good as patients receiving carboplatin and paclitaxel.
The phase III multi-national European trial involving 618 patients with advanced non
A research team at two Midwest universities has developed a new way to genetically alter cells in living mice, offering new possibilities in the war against cancer and other diseases.
Using a modified virus as a Trojan horse, a team led by Purdue Universitys David Sanders has found a promising system to deliver genes to diseased liver and brain cells. By placing helpful genetic material within the outer protein shell of Ross River Virus (RRV), Sanders team was able to alter the
Companies that create HIV-AIDS drugs now have key information that could assist in making new medications with fewer side effects.
Researchers Henry Weiner, a professor of biochemistry at Purdue University, Steven Zollo of the National Institute of Standards and Technology and Lauren Wood of the National Cancer Institute, noted the similarity between HIV-AIDS treatment side effects and naturally occurring diseases. Certain HIV-AIDS treatment side effects, such as fat loss and insulin resista
A team led by Terumi Kohwi-Shigematsu of Lawrence Berkeley National Laboratory’s Life Sciences Division has demonstrated that SATB1, a protein crucial to the development of the immune system, works by forming a network in the cell nucleus, attaching chromatin to the network structure at specific sites, and orchestrating remodeling of the chromatin over long distances to regulate gene expression.
“SATB1 determines when and how the genes are read — when they are activated and when they are
Using an optical fluorescence microscope to monitor enzyme activity, researchers at three universities have solved a long-running mystery. It takes at least two proteins, working in an unstable tandem, to unzip two strands of DNA.
Their newly designed approach, which focuses on the activity of single molecules, also showed — for the first time — that if one protein falls away, the process stops. Unless another climbs aboard, DNA reverts to its zipped state.
The technique, which o
Ribosome Recycling Factor Mimics Shape, But Not The Functions of Transfer RNA
RRF Protein Offers Potential Target for New Antibiotics
The fact that ribosome recycling factor (RRF) looks a lot like transfer RNA (tRNA) has not been lost on scientists. After all, both molecules are an important part of a bacterias ability to create new proteins. Researchers at the University of Pennsylvania School of Medicine and the University of Southern California, Santa Cruz, however, hav
Researchers from Delft University of Technology in The Netherlands have been able to initiate a controlled movement in the very heart of an atom. They caused the atomic nucleus to…
The integration of efficient, scalable, and cost-effective nanoscale lasers is essential for optical interconnects, medical diagnostics, and super-resolution imaging. Particularly, telecom-band NW lasers are promising for on-chip coherent light sources…
Smile for the camera! An interaction between an elliptical galaxy and a spiral galaxy, collectively known as Arp 107, seems to have given the spiral a happier outlook thanks to…
Research led by the Institute for Bioengineering of Catalonia (IBEC) has studied the migratory movement of groups of cells using light control. In processes such as embryonic development, wound healing…
Brigham researchers develop strategy to improve immunotherapy by helping T cells penetrate and kill tumor cells. Fighting cancer is exhausting for T cells. Hostile tumor microenvironments can drain their mitochondrial…
New method developed by researchers of KIT and voxalytic GmbH allows easy elucidation of the spatial arrangement of atoms –tool for drug discovery. The chirality of a molecule refers to…
The global use of lithium-ion batteries has doubled in just the past four years, generating alarming amounts of battery waste containing many hazardous substances. The need for effective recycling methods…
A new study led by researchers at the University of Minnesota Twin Cities is providing new insights into how next-generation electronics, including memory components in computers, breakdown or degrade over…
How synthesis methods have a profound impact on disordered materials. A new study reveals how different synthesis methods can profoundly impact the structure and function of high entropy oxides, a…
The AQT quantum computer, featuring 20 qubits based on trapped-ion technology, is now operational at LRZ’s Quantum Integration Centre (QIC), making it the first of its kind in a computing…
The CHAI joint project aims to optimize corrosion management in ports and waterways. The federal state of Schleswig-Holstein is funding the CHAI research project with a total of 900,000 euros….
A research team from the Scuola Superiore Sant’Anna in Pisa has developed the prosthesis of the future, the first in the world with magnetic control. It is a completely new…