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miRNA Maturation Assay – Screening Tool for Specific miRNA Maturation Inhibitors

The micro RNA maturation assay offers the opportunity to screen for small molecules influencing the dicer-mediated maturation process of miRNAs. miRNAs are…

Immunosuppressive Effect of a Plant Extract

Inventors could demonstrate the potential effect of a new plant extracts in prophylaxis and treatment of inflammatory and/or neurological diseases, like…

Immunotherapy with Tumour-Associated Antigens Derived from PAX2 and PAX8

Immunogenic T-cell epitopes from PAX2 and PAX8 have been found as promising immunotherapy against renal, colorectal, breast and ovarian cancer.Further…

Nematode Derived Cystatin Inhibits Allergic Airway Responses and Inflammation

A parasitic nematode derived cystatin (Av17) suppresses allergic airway responsiveness in a murine model of ovalbumin-induced allergy. This was combined with…

Use of an Ang-(1-7) Receptor Agonist in Acute Lung Injury

With age-adjusted incidences of 86 per 100.000 person-years and overall mortality rates of about 43%, acute lung injury (ALI) and its most severe form, the…

Bone Reconstruction / Fracture Healing: BMP2 Variants with Reduced BMP Antagonist Sensitivity

The novel method acts by replacing central residues and domains within BMP2 which are of prime importance for the specific interactions with its inhibitors….

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