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Tuberculosis is an extremely insidious disease. The pathogen Mycobacterium tuberculosis can rest undetected many years in the human body, and infected people show no symptoms – until the disease suddenly breaks out. Worldwide, the number of deaths related to tuberculosis amounts to 2 million per year, eight million new infections occur annually. Dangerous centers of infection are, for instance, third-world countries or prisons in countries of the former Soviet Union. In some of the prisons, one hu

A EU-sponsored project has developed a suite of tools that will enable biotech companies to mine through vast quantities of data created by modern life-science labs to find the nuggets of genetic gold that lie within.

The BioGrid project brought together six partners from the UK, Germany, Cyprus and The Netherlands to address one of the key problems facing the life sciences today.

“How to integrate the huge volume of disparate data – on gene expression, protein interactio

A team of ophthalmologists at the University of Liverpool has become the first in the world to image geodesic structures – called CLANs – inside the human body.

Professor Ian Grierson and his colleagues have found that the shape of each CLAN is similar to the design of the framework forming the roofs over the Eden Project and the courtyard at the British Museum.

CLANs is an acronym for Cross-linked Action Networks. They are formed from the components which maintain the str

Experts in ancient DNA from McMaster University (Canada) have teamed up with genome researchers from Penn State University (USA) for the investigation of permafrost bone samples from Siberia. The project also involved paleontologists from the American Museum of Natural History (USA) and researchers from Russia, the United Kingdom, France, and Germany. The researchers’ report on the first genomic sequences from a woolly mammoth will be published on 22 December 2005 by the journal Science on

A collaboration between scientists at UCLA, Caltech, Stanford, Siemens and Fluidigm have developed a new technology using integrated microfluidics chips for simplifying, lowering the cost and diversifying the types of molecules used to image the biology of disease with the medical imaging technology, Positron Emission Tomography (PET). These molecules are used with PET to diagnostically search throughout the body to look for (image) the molecular errors of disease and to guide the development of

Through the Human Genome Project, the HapMap Project and other efforts, we are beginning to identify genes that are modified in some diseases. More difficult to measure and identify are the regulatory regions in DNA – the ‘managers’ of genes – that control gene activity and might be important in causing disease.

Today, a team led by the Wellcome Trust Sanger Institute, together with colleagues in the USA and Switzerland, provide a measure of just how important regulatory region var