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Sisyphean movement of motor proteins may help preserve DNA integrity

Researchers studying how proteins called helicases travel along strands of DNA have found that when the proteins hit an obstacle they snap back to where they began, repeating the process over and over, possibly playing a preventative role in keeping the genome intact.

Taekjip Ha, a professor of physics at the University of Illinois at Urbana-Champaign and a Howard Hughes Medical Institute investigator, likens the biological scenario to Boston Red Sox baseball; the team rolls along

Color Perception Is Not in the Eye of the Beholder: It’s in the Brain

First-ever images of living human retinas have yielded a surprise about how we perceive our world. Researchers at the University of Rochester have found that the number of color-sensitive cones in the human retina differs dramatically among people—by up to 40 times—yet people appear to perceive colors the same way. The findings, on the cover of this week’s journal Neuroscience, strongly suggest that our perception of color is controlled much more by our brains than by our eyes.

Expression Project for Oncology (expO) collects 1,000th malignant tumor specimen

Clinically annotated results are publicly available online

The International Genomics Consortium’s (IGC) Expression Project for Oncology (expO) today announced that it has collected its 1,000th frozen cancer specimen, which exceeds original expectations for the project while marking a milestone that is recognized by researchers, industry and academia. Gene expression analysis with clinical information on hundreds of these specimens is now publicly available online.

Leeches provide source for cardiovascular drugs

The leech has recently confirmed its biomedical interest for scientists by showing that it contains an extensive list of new potential molecules that may become useful tools in the treatment of cardiovascular diseases. The details of this research appear in the October issue of Molecular and Cellular Proteomics, an American Society for Biochemistry and Molecular Biology journal.

Scientists have increasingly turned to blood-feeding invertebrates as a source for drugs and lead c

Purdue findings help Coast Guard modify search-and-rescue plane

Purdue University engineers are helping the U.S. Coast Guard deal with a possible 10-fold increase in vibration that could result from installing a larger observation window in a search-and-rescue aircraft to improve visibility during missions.

Presently, the Lockheed Martin HC-130J Hercules search-and-rescue plane has a circular observation window that is about a foot in diameter, and the Coast Guard would like to install a window that is about 4 feet long by 3.5 feet wide.

Missouri genetic disorder’s roots untangled by international team

An international team of researchers has partially untangled the genetic details of a mysterious disorder that formerly caused seizures and death in infant boys within a month of birth.

The researchers discovered a rare change in the DNA of two eastern Missouri families with a history of a condition called X-linked recessive idiopathic hypoparathyroidism (XLHPT): a portion of the X chromosome, a human sex chromosome, has been removed and replaced by a copy of a much larger sectio

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