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New source for heart bypass replacement blood vessels: Fibrin-based TEVs

Fibrin gel matrix-based vessel ready for test transplantation after only two weeks in culture

The search for a stable, renewable source of blood vessels, especially for potential use in heart bypass surgery, has reached a milestone at the State University of New York at Buffalo. A multi-disciplinary team at SUNY Buffalo designed tissue engineered blood vessels (TEVs) using a matrix of vascular smooth muscle embedded in fibrin gels. After only two weeks in culture, the TEVs show

Gene Therapy: the Search for the Safe and Gentle Method

Scientists from three countries study innovative DNA transport element

Treating genetic diseases by introducing functional genes into the human organism: researchers from three European countries are aiming for a breakthrough in this process, known as gene therapy, using a new methodology. The network of scientists, including the German Research Centre for Biotechnology in Braunschweig (GBF), is working to further develop a certain type of DNA element, called an episome, for this

Serum caspase activity and liver fibrosis in patients with hepatitis C

Caspase levels are associated with liver injury

Caspase activity in the sera of patients with chronic hepatitis C infection (HCV) may be a more sensitive measure of liver injury than conventional surrogate markers like aminotransferases, according to a new study published in the November 2004 issue of Hepatology. Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD), published by John Wiley & Sons, Inc., is available online via Wiley

Deciphering the Arctic Ocean Climate Puzzle

In August and September of this year, three powerful icebreakers transited to the North Pole in search of a climate record stored in sediments below the Arctic Ocean floor. During the spectacular Arctic Coring Expedition (ACEX), conducted by the Integrated Ocean Drilling Program (IODP), 340 meters of sediment core were retrieved from the bottom of the Arctic Ocean — a true “first.” With these sediments in hand, earth scientists for the first time can move away from pure speculation about the

Stress impairs thinking via mania-linked enzyme

An errant enzyme linked to bipolar disorder, in the brain’s prefrontal cortex, impairs cognition under stress, an animal study shows. The disturbed thinking, impaired judgment, impulsivity, and distractibility seen in mania, a destructive phase of bipolar disorder, may be traceable to overactivity of protein kinase C (PKC), suggests the study, funded by the National Institutes of Health’s (NIH) National Institute of Mental Health (NIMH) and National Institute on Aging (NIA), and the

Sound Filters Light

Russian researchers have developed a small, smart and tolerant to vibrations spectrometer, which is equally reliable in the outer space and in oceanic depths. The development was performed with financial support from the Russian Foundation for Basic Research (RFBR) and the Foundation for Assistance to Small Innovative Enterprises (FASIE). The unique device is based on a completely new principle: the light goes through an acoustooptical filter in the device.

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