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They hadn’t planned it, but Meriwether Lewis and William Clark picked a fine time for a road trip when they set out to find a water route across the American Northwest two centuries ago.
Leading a small group of explorers, known as the Corps of Discovery, Lewis and Clark experienced favorable climatic conditions from 1804 to 1806 in search of an inland “Northwest Passage,” according to a Georgia State University professor.
The timing of the trip was crucial because ha
Howard Hughes Medical Institute researchers have identified a telltale change in cellular machinery that could help clinicians predict whether prostate cancers are likely to spread or remain relatively harmless in the prostate.
The researchers found that a cellular signaling molecule called Hedgehog, which drives normal development and regeneration of prostate tissue, is greatly activated in prostate cancers. This elevated activity distinguishes dangerous metastatic cancers – those t
IL-7, a hormone-like protein involved in cell-cell interaction, has been associated with increased survival and expansion of T-cell acute lymphoblastic leukaemia (T-ALL). Now, in the latest issue of the Journal of Experimental Medicine, a team of scientists, not only confirms the essential role of this protein in the disease but also, for the first time, identifies the biochemical pathway affected by IL-7 in T-ALL cells, a discovery which could lead to the development of potential new treatments
Painful and damaging chemotherapy may one day be a thing of the past. Researchers at the Georgia Institute of Technology and Purdue University have developed nano-sized particles that can target and trick cancer cells into absorbing them. Once inside, the particles may soon be able to deliver a pharmaceutical payload, killing the tumor from within, avoiding the destruction of healthy cells responsible for much of the damage caused by traditional chemotherapy. The research is published in the Augu
At the Institute of Physics conference Photon 04 yesterday, Professor Jim Hough, one of the UK’s leading scientists, revealed that he thinks high street bookmakers are crazy to be offering odds of 100-1 on whether Gravitational Waves (wrinkles in relativity) will be discovered before 2010. He has placed a personal bet of £25 – the maximum Ladbrokes allowed him to stake. The available odds were quickly cut from an initial offering of 500-1.
Professor Jim Hough, from the Universi
By mimicking a molecular switch that triggers cell death, researchers have killed cells grown in the laboratory from one of the most resilient and aggressive cancers – a virulent brain cancer known as glioblastoma. The new approach to tricking the cell-death machinery could be applied to a wide range of cancers where this pathway, known as apoptosis, has been inactivated.
The researchers — led by Xiaodong Wang, a Howard Hughes Medical Institute investigator at the University of Tex