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How the cellular ’garbage disposal’ grinds to a halt to cause Batten disease

Scientists have discovered just how a genetic defect disrupts the cellular “garbage disposal” of a cell, resulting in a horrific childhood disease that kills most patients before the age of 25.

For nine years researchers have known the precise genetic flaw that causes Batten disease. But understanding how a straightforward mistake in life’s blueprint translates to a disease that ravages roughly 1,000 children in the United States each year has been a challenge. Now, in a paper in the D

Elves make protein crystallography easier

Scientists are finding a computer program called Elves to be a nearly magical solution to the tedious and time-consuming task of determining the 3-D shape of proteins – a major focus of cutting-edge proteomics today – from X-ray diffraction data.

According to Elves developer James Holton, who recently received his Ph.D. from the University of California, Berkeley, researchers can unleash Elves on a set of X-ray diffraction data and go on to other things – or take a nap – while the computer

Statistics research offers new forecast of El Niño

A statistical model from Ohio State University is forecasting sea surface temperatures in the tropical Pacific Ocean in a new way.

The model gives scientists a way to quantify the uncertainty that surrounds the climatic phenomenon known as El Niño, which triggers severe weather changes in North and South America and Australia and endangers crops and wildlife, said Noel Cressie, professor of statistics and director of the university’s Program in Spatial Statistics and Environmental Sci

New type of nanotube made of gold or silver created at the Weizmann Institute

Weizmann Institute scientists have created a new type of nanotube built of gold, silver and other nanoparticles. The tubes exhibit unique electrical, optical and other properties, depending on their components, and as such, may form the basis for future nanosensors, catalysts and chemistry-on-a-chip systems.

The study, published in Angewandte Chemie, was performed by Prof. Israel Rubinstein, Dr. Alexander Vaskevich, postdoctoral associate Dr. Michal Lahav and doctoral student Tali Sehayek,

Search for screening method to help decide when early-Alzheimer’s patients should stop driving

Meta-analysis of 27 studies showed caregiver reports may be unreliable; visuospatial tests were the best predictors of driving skill

When cognitive skills start fading, how do we know when it’s time to stop driving? Although there is some consensus that individuals with moderate to severe dementia should not drive, it has been much harder to screen people with mild dementia, the earliest stage of the mental deterioration typical of Alzheimer’s disease. Researchers in Washing

Progress in probing the mosquito’s sense of smell

Researchers find odorant in human sweat that attracts female mosquitoes

Today, we know a little bit more about one of mankind’s deadliest enemies, the mosquito. Scientists have taken an important step toward understanding the mosquito’s sense of smell, an avenue of research that may lead to better ways to repel the deadly insect.

In a joint effort reported in the Jan. 15 issue of the journal Nature, researchers at Vanderbilt and Yale universities have verified that

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