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New work by researchers in the Kimmel Cancer Center at Johns Hopkins may allow them to halt the smoking-induced cellular events that lead to 99 percent of all small cell lung cancers (SCLC). The research is reported in the March 5, 2003, issue of Nature.

The researchers found that a primitive cellular pathway, called Sonic Hedgehog (named for the cartoon character and spiky hairs it develops on fruit flies) stays turned on long after it should be turned off in some lung cancers.

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New research into the origin of kidney stone formation published in the March 1 issue of the Journal of Clinical Investigation may well change the direction of the most basic level of research in that area.

The study, conducted at Indiana University School of Medicine, Clarian Health Partners and the University of Chicago, will dispel the current beliefs of where stone formation begins, said Andrew P. Evan, Ph.D., the article’s lead author. Dr. Evan, who is a professor of anatomy and c

Fruits and veggies grown organically show significantly higher levels of cancer-fighting antioxidants than conventionally grown foods, according to a new study of corn, strawberries and marionberries. The research suggests that pesticides and herbicides actually thwart the production of phenolics — chemicals that act as a plant’s natural defense and also happen to be good for our health. Fertilizers, however, seem to boost the levels of anti-cancer compounds.

The findings appear in the

Scientists with the U.S. Department of Energy’s Joint Genome Institute (JGI) and the Lawrence Berkeley National Laboratory (Berkeley Lab) have developed a powerful new technique for deciphering biological information encoded in the human genome. Called “phylogenetic shadowing,” this technique enables scientists to make meaningful comparisons between DNA sequences in the human genome and sequences in the genomes of apes, monkeys, and other non-human primates. With phylogenetic shadowing, scientists c

University of Colorado at Boulder researchers have conducted the most sensitive search to date for gravitational-strength forces between masses separated by only twice the diameter of a human hair, but they have observed no new forces.

The results rule out a substantial portion of parameter space for new forces with a range between one-tenth and one-hundredth of a millimeter, where theoretical physicists using string theory have proposed that “moduli forces” might be detected, according to

Forget sharp metal picks or X-rays-in the future, your dentist may search for cavities using a painless laser-based technique developed at U of T that can detect cracks or defects at an early stage of development. v “Using the technique, we can see all the way to the pulp-more than five millimetres inside a tooth,” says Professor Andreas Mandelis of U of T’s Department of Mechanical and Industrial Engineering. “It can reveal suspicious regions invisible to the naked eye below the surface of