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A gene thought to keep a single X chromosome turned on in mice plays no such role in humans, Johns Hopkins researchers report in the August issue of the American Journal of Human Genetics.

The finding is likely to relegate the disproven gene to relative obscurity, at least in humans, says Barbara Migeon, M.D., of the McKusick-Nathans Institute of Genetic Medicine, whose laboratory found the human version of the gene in 2001. It also moves the search for the gene from the X chromosome to the

Researchers at Case Western Reserve University have discovered kinks in aggrecan, a widely studied protein at the submolecular root of arthritis, a finding that brings scientists closer toward new drugs and other interventions to prevent or alleviate the disease. “Aggrecan acts to organize and densely pack sugar molecules that give cartilage its resilience,” said Steven Eppell, an assistant professor of biomedical engineering and director of the Nanoscale Orthopedic Biomaterials Labo

Studies might improve understanding of leading cause of mental retardation in girls By studying gene mutations in patients with the complex set of behavioral and neurological symptoms that accompany Rett syndrome, Howard Hughes Medical Institute investigator Huda Zoghbi and her colleagues at Baylor College of Medicine have designed a mouse model that faithfully recapitulates the disease down to its distinctive hand-wringing behavior. The development of the mouse, reported in the July

After 40 years of searching for the photoreceptor that controls multiple vital processes in fungi, researchers at UT Southwestern Medical Center at Dallas have discovered the protein that triggers this phenomenon.

Light regulates several physiological processes in fungi, including their ability to produce spores and the synchronization of their internal biological clocks, but their photoreceptors – receptors that are sensitive to light and are essential for most ongoing processes – were not

UC Berkeley scientist urges drilling into frozen lake under ice near South Pole as prelude to drilling into subglacial lakes in Antarctica and into Mars polar caps

Measurements of the ice temperature far below the South Pole suggest that a so-called “lake” discovered at the base of the ice is most likely permafrost – a frozen mixture of dirt and ice – because the temperature is too low for liquid water.
Far from being a disappointment, says a University of California, Berkeley p

Almost half of the first top 10 websites displayed by leading search engines on vaccination are emotive “anti” sites, finds a study in the Archives of Disease in Childhood. Many masquerade as official scientific sites, making it easier for users to be misinformed, say the authors.

The researchers keyed in the terms “vaccination” and “immunis(z)ation” into seven leading search engines: Google; Netscape; Altavista; GoTo; HotBot; Lycos; and Yahoo. They then used just the term “vaccination,” for