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Colorectal cancer (CRC) is the third most frequently occurring cancer in both sexes. It ranks second in developed countries. Tumor growth beyond the critical two to three millimeter diameter and metastasis require angiogenesis. Therefore, in later tumor stages, antiangiogenic treatment offers a strategy that has been shown in clinic to improve outcomes in patients with advanced or metastatic colorectal cancer (mCRC). Today, several antiangiogenic drugs for tumor therapeutic application have been approved, e.g. Bevacizumab (Avastin®), Cetuximab (Erbitux®) or Panitumumab (Vectibix®). Nevertheless, 20% of the patients do not respond and are resistant to antiangiogenic therapy.
This invention provides a method which allows to further improve the efficacy of antiangiogenic therapy in colorectal cancer (CRC). This is achieved by detection and exclusion of patients, which are in a therapy resistant tumor stage.
The events triggered when sperm meets an egg are not only life changing for the parents but deeply fascinating from a scientific point of view, too.
A new study published in Geology uses pockets of melts trapped within crystals to understand the conditions occurring beneath volcanoes before explosive…
The present invention uses a Peltier cooling instead of the usual nitrogen cooling and therefore shows an improved separation device for impurities, especially gaseous impurities, and, com-pared to the state of art, an improved pump device.
A group of researchers from the National Astronomical Observatory of Japan (NAOJ), the University of Tokyo, and the Astrobiology Center among others has…
Analytical cell-based assays used in diverse applications such as the risk assessment of chemicals and the investigation of stem cell propagation stages, currently employ adherent cell lines. This cell type comes with serious drawbacks. Most importantly, extensive measures are needed for propagation purposes. Intriguingly, scientists at RWTH Aachen University have invented a method of stably growing any analytical (reporter) cell line in suspension. This enables high cell density growth and bulk applications towards tissue engineering, as well as toxicity testing. Furthermore, the method profoundly enhances high-throughput screening efficiency.