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During a joint research project scientists at the University of Stuttgart and the University of Konstanz developed an ECM with functional groups (clickECM) which is covalently and thus firmly bonded to surfaces via bioorthogonal ligation reactions. The fixed bonding obtained through the click reaction also ensures that the clickECM coating, e.g. when used for cell culture vessels, withstands extensive washing. The coating is highly stable and can be produced economically without any costly purification or isolation processes. The clickECM only differs from a natural ECM in terms of the introduced functional group.

Scientists of the University of Duisburg-Essen developed a platform, which facilitates the detection of deletions and insertions as well as point mutations in target genes from a variety of sources against a huge background of wild type alleles, making a clear “Yes” or “No” output possible and thereby simplifying therapeutic decisions.
Neither expensive and complicated equipment nor specialized personnel is needed. The assay is robust and applicable in all laboratories equipped with an RT-PCR machine. It can easily be established for point of care (PoC) purposes.
This sensitive technology now enables clinicians to be independent of the scarce resource “tissue biopsy”. By using blood (ctDNA, cfDNA or CTC) it opens new non-invasive possibilities for monitoring the mutation status of patients before and during treatment as well as to detect disease relapse early. A European and a US patent have already been granted, other applications are pending.

Bathing a patient in LED light may someday offer a new way to locate tumors, according to Rice University researchers.

Invention is used for additive manufactur-ing of parts out of amorphous or partly crystalline metals with low melting point. This is done with an extrusion method. The used material, metal granulate, is heated up to the glass transition temperature and partly up to the melting temperature. By doing so, the material is moved into a thermoplastic state. After heating, the material can then be extruded by pressure and is selectively placed onto a building platform. The system described in this invention is able to manufacture hollow constructions along with complex parts, all with good mechanical properties. Due to the generating of the part onto the building platform it is not necessary to clean or post process the part as it would be with other methods.

Staphylococcus aureus is a bacterium that is frequently found on the human skin and in the nose where it usually behaves inconspicuously. However, once inside…