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The findings, scientists indicate, are some of the most compelling ever produced in the search for a therapy for ALS, a debilitating and fatal disease, and…

The invented substances have been characterized with regard to the inhibition of the cPLA2 (IC50 in the submicromolar range) and metabolic stability (tested in rat liver homogenates). The inventors are currently conducting such experiments with further, newly generated derivatives of the same inhibitor family. On behalf of the Westfalian Wilhelms-University of Muenster, PROvendis offers access to rights for commercial use as well as the opportunity for further co-development. The cPLA2 has been identified as target for the inhibition of inflammatory immune responses. The invented substances are of high interest for any pharma company with an immunological pipeline and may constitute the first-in-class cPLA2 inhibitors for systemic application.

Parkinson's disease (PD) is a neurological movement disorder. Atypical Parkinson syndromes arise from other neurodegenerative diseases like Dementia with Lewy bodies (DLB). The accurate distinction between them is challenging. Our scientists developed a new diagnostic test to differentiate between DLB, PD and other neuropathies.

For two-dimensional film thickness determination, a measurement system based on a hyperspectral imager has been developed for the first time. A head forms a measurement line. Reflection of the measurement object is displayed on the entrance slit of the hyperspectral imager. From the spectral reflectance data of each locally resolvable pixel of the examined object the layer height is reconstructed. If the measurement object is moving uniformly, combined measurement lines are resulting in a two-dimensional measuring surface. In addition, for each locally resolvable pixel the distance between head and measurement object can be determined.

Liang Fang and his colleagues in Walter Birchmeier's group at the Max Delbrück Center for Molecular Medicine (MDC), working with colleagues on the Berlin-Buch…

Around 1100 open clusters have so far been discovered within the Milky Way, although many more are thought to exist. Trumpler 14 is one of these, located some…