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Functional surface modification inspired by the mussel adhesive protein – the most stable adhesive in nature

Permanent and stable surface coatings are suitable to be achieved on medically relevant metals (e.g. titanium) and glass via trimeric catechol derivatives. Furthermore, various active agent molecules such as PEG, antibiotics, enzymes and other biomolecules may be coupled to natural molecules by means of simple chemical reactions (?click reactions?). The new tripodal ligands offer considerable advantages in comparison to the state of the art monovalent metal binders currently used.

Humanized anti-CCR2 Antibody for the Therapy of MS and RA

Scientists of the University of Göttingen and of the University of Regensburg developed in collaboration a proprietary anti-CCR2 antibodies for the therapy of Multiple Sclerosis (MS) and potentially Rheumatoid Arthritis (RA).The lead candidate Doc-2 has been humanized in collaboration with the MRC Technologies. It targets the CCR2 receptor and modulates the autoimmune process through depletion of CCR2+ monocytes.

MagnetWeft – Magnetic Weft Insertion in weaving machines

The object of the invention was hence to develop a weaving method of weft insertion that combines the advantages of the common methods whilst avoiding their deficits. This will be achieved with a magnetic projectile which is used for the guided transport of the yarn. The projectile is moved through the open shed by magnets, which are mounted on a belt. The belt is located outside of the shed. Multiple projectiles can be used simultaneously to ensure a high efficiency of the weft insertion.
The magnetic weft insertion represents an energy-efficient alternative to the standard weft insertion methods. The fact that production velocities of yarns with challenging processing characteristics can be similar to the ones of standard yarns is certainly an advantage. In magnetic weft insertion no source of compressed air is necessary, a reduction of energy consumption of about 60 % compared to a conventional air jet weaving machine is to be achieved.

Softwood with increased Hardness + Durability for the European and US market

Non-toxic wood treatment of wood (with DMDHEU impregnation process) to increase durability, hardness, stability and weather & water resistance of domestic softwood (like beech, pine, ..) to achieve top-quality tropical-like woods. Value added products can be created opening new markets for domestic softwoods.

New Hexaorgano guanidinium or-gano carbonates and related salts for use in batteries, chemical syntheses (e.g., SILP), biological applications

The invention provides novel hexaorgano guanidinium or-ganocarbonates that can be used to produce other hexaorgano guanidinium salts through anion metathesis. The metathesis reaction according to the invention is highly efficient, as it enables quantitative production of the hexaorgano guanidinium salts. The method also avoids toxic byproducts. Both the hexaorgano guanidinium organocarbonates and hexaorgano guanidinium salts obtainable therefrom are halide-free ionic liquids and are thermally stable. They have many potential applications, for example in chemical syntheses, adsorption heat pumps, and elec-trolyte systems (e.g., batteries, photovoltaics).

Biotechnological [S,S]-EDDS Production

The complexing agent ethylenediamine-disuccinate (EDDS) is an ethylenediamine-tetraacetate (EDTA) isomer. EDTA is widely used in paper, textile, and laundry industry but also as cosmetic, food, and medical additive. Due to its poor degradability, EDTA became an environmental hazard. EDDS has similar complex-forming properties as EDTA. In contrast to EDTA, the isomer [S,S]-EDDS is biode-gradable. Therefore, a chemical process to produce [S,S]-EDDS had already been established. Howev-er, the chemical synthesis is not only expensive but also complicated.
A biotechnological large scale production of [S,S]-EDDS was not possible until now, because already 2 μM zinc, a concentration occurring ubiquitously in standard media, inhibits the synthesis of [S,S]-EDDS. Here we present a process to synthesize [S,S]-EDDS biotechnologically using an optimized Amycolatopsis japonicum strain, that produces [S,S]-EDDS in the presence of zinc and in complex media (see Figure 1).

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