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The present technology improves immunogenicity by treating DCs during maturation with the fungal-derived enzyme galactose oxidase. Hereby, a stronger physical interaction between DCs and T cells is achieved resulting in an at least 10-fold improved T cell priming capacity. In cell culture assays both human and mouse DCs showed enhanced T cell priming potential, the murine cells also in vivo.
Even the T cell stimulatory potential of mature DCs that were putatively activated up to a maximum was further improved by the galactose oxidase treatment. Hence, low affine T lymphocytes, as often found in the context of tumor antigens, can be activated and brought to proliferation too.
By improving T cell priming capability and therefore immunogenicity, this technology provides the opportunity to markedly enhance the classical DC maturation and accordingly to improve DC-vaccine approaches for example in tumor or HIV patients.
As many other stars, AU Microscopii is surrounded by a dust disk. Now researchers – including scientists from the Max Planck Institute for Astronomy in…
As the first dedicated camera for the E-ELT, MICADO will equip the giant telescope with a capability for diffraction-limited imaging at near-infrared…
This invention is a process for detecting salmonellae as well as a fluorescing detection molecule that can be used for detecting salmonellae. This procedure enables the rapid, sensitive, and specific detection of salmonellae. A major advantage of this invented technology is that the salmonellae biosensor described here requires no additional devices aside from a fluorescence reading device, and does not require any specially trained technical experts.
This process enables the production of functional fusion tissue of various sizes. One advantage over previous procedures is that it generates larger fusion tissue that is also improved in its differentiation and functionality. The invented fusion tissue is also suitable for screening for new substances, to test substances, to improve or validate known therapeutic substances, or to create new indications and applications for known substances.
In the recent work published today in Nature Nanotechnology, the research group led by Prof at ICFO Frank Koppens has shown that a two-dimensional crystal,…