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Solid state polymer electrolyte membrane

Method for production of a mechanical stable and flexible polymer based ion conducting solid state polymer electrolyte membrane for the use in lithium based accumulators.

Drug discovery for Parkinson's disease: LCSB researchers grow neurons in 3-D

The scientists working with Dr. Ronan Fleming of the LCSB research group Systems Biochemistry are confident this system could greatly facilitate the continuing…

Regenerative storage system with fuel synthesis

The invention describes a combined electricity generation and storage system, preferably based on renewable burnable gases e.g. from biogas plants or biomass gasification.

Cockroach-inspired robot uses body streamlining to negotiate obstacles

Fitted with the characteristic rounded shell of the discoid cockroach, the running robot can perform a roll manoeuvre to slip through gaps between grass-like…

What Droppings Can Tell Us

Eurasian otters are elusive creatures. Only rarely do researchers manage to observe these shy animals directly in the wild. Trampled vegetation at the water's…

SMA therapy approach – Down-regulation of NCALD in spinal muscular atrophy and diseases with a disturbed calcium homeostasis

Spinal muscular atrophy (SMA) is an autosomal recessive disorder based on the loss of the survival motor neuron 1 (SMN1) genes. The severity of the disease is inversely correlated with the copy number of the main disease modifying gene SMN2.
In rare cases, siblings of SMA patients do not show SMA, although they carry exactly the same SMN1 and SMN2 gene status as their SMA affected relatives. So other genetic factors are able to fully protect homozygously SMN1-deleted individuals from developing SMA. The inventors found that this phenomenon might be caused by the overexpression of plastin 3, an actin-bundling protein, and/or low expression levels of the calcium sensing protein neurocalcin delta (NCALD). In vitro and in vivo studies show that inhibitors of neurocalcin delta (NCALD) are suitable for treating and preventing such disorders in a patient. Said inhibitors are, likewise, effective tools for in vitro neuronal differentiation and maturation, and restoration of impaired endocytosis.

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