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In so doing, Dr Clara Hoppe and her team have overturned the widely held assumption that sinking pH values would stimulate the growth of these unicellular…
The life style of ectomycorrhiza fungi is some 100 million years younger than the one of their ancestors within white and brown rot fungi. The key genome…
Perfusion analysis in animal models (e.g. myocardial infarction) is currently determined by using fluorescent particles or dyes that are injected into circulation. They distribute throughout all blood vessels and stain them permanently. Thus it is possible to distinguish areas that are supplied with blood and those that are not. Since the dyes are long-lasting in the tissues they interfere with subsequent methods of analysis. A model animal that is used for perfusion analytics can therefore only be used for this specific analytical method.
The present invention overcomes these drawbacks by injecting non fluorescent inert particles that are the first component of an orthogonal system. After perfusion with these particles, the second component is added to frozen tissue sections of interest. Thus, perfusion analysis is solely performed on a selected tissue section, without any limitations for the remaining tissue.
This approach allows a background-free subsequent tissue analysis, optimizes data harvest, is economic and reduces animal consumption.
The findings appear Feb. 23 online in the journal Environmental Health Perspectives. A PDF is available on request.
Scientists searching for signs of elusive “dark photons” as an explanation for an anomaly in a groundbreaking physics experiment have nearly ruled out their…
While public interest on possible extrateestrial life is increasing, only a fraction of the biodiversity of our own planet is known. Current estimates suggest…