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VISTA stares right through the Milky Way

As one of its major surveys of the southern sky, the VISTA telescope at ESO's Paranal Observatory in Chile is mapping the central regions of the Milky Way in…

New mechanism of inheritance could advance study of evolution, disease treatment

For more than a century, scientists have understood the basics of inheritance: if good genes help parents survive and reproduce, the parents pass those genes…

Scientists trial system to improve safety at sea

Concept uses satellite technology already in orbit to take images of sea
Enables ship and plane movement to be pinpointed to much more accuracy
Data can be…

Low Cost Sensor for Online-Monitoring of Formaldehyde

So far the analysis of indoor concentrations of formaldehyde is only possible via expensive methods, normally requiring GC or HPLC analysis in the lab. So called MOX (metal oxide) sensors theoretically permit an online-monitoring, but there is so far no instrument available for the detection of relevant concentrations in the ppb-range at reasonable costs.
Our invention presents a novel MOX-sensor based on In4Sn3O12 as sensitive layer with sensitivities for formaldehyde being two orders of magnitude above those of established reference sensors. Our sensor allows an online/realtime-monitoring of formaldehyde in day to day settings, at low cost.

Building trustworthy big data algorithms

Much of our reams of data sit in large databases of unstructured text. Finding insights among emails, text documents, and websites is extremely difficult…

Druggable oncogenic fusions – NRG1 Gene Fusions as Markers & Targets for Various Cancers

Cancer patients frequently bear therapeutically relevant genome alteration. For instance, lung adenocarcinomas of patients that have never smoked carry genome alterations affecting kinases, such as EGFR mutations and translocations affecting ALK, ROS1, and RET genes. These patients can be effectively treated with an ever-growing number of kinase inhibitors. However, despite substantive cancer genome sequencing efforts a majority of tumors still lacks therapeutically tractable alterations. Scientists of the University of Cologne identified NRG1 gene fusions as ideal diagnostic and prognostic markers and targets for various tumours. The MTSS1-NRG1 fusion event has e.g. been detected in patients with small cell lung cancer and the gene fusion CD74-NRG1 has been shown to occur frequently in never smokers with invasive mucinous lung adenocarcinoma lacking KRAS mutation. The latter has been verified by several other groups.

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