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Virus-like particles (VLPs) of EBV, completely devoid of viral DNA, for the prevention of infectious mononucleosis (IM) and EBV-associated diseases like lymphomas often developed in patients with immunosuppression.
In 50-80% OPSCC patients human papilloma virus (HPV) can be detected. These patients have an improved survival and would benefit from deescalate cancer treatment. The technology provides a reliable marker based on RNA pattern.
DKFZ inventors identified the Wnt secretion protein Evi/Gpr177 as new target, which is strikingly upregulated during glioma tumorigenesis in a stage-independent way and which correlated with poor prognosis. Silencing of the Evi/Gpr177 protein significantly inhibited glioma cell proliferation and migration. Additionally an inhibitory antibody against Evi/Gpr177 was invented that significantly reduced Wnt Evi/Gpr177 gene response.
Currently, multi leaf collimators (MLC) are established and state of the art in numerous devices for radiotherapy used for cancer treatment. However, the established MLC comprising 80 and more leafs require an enormous space at the level of the leaves for corresponding drive and controlling elements if realized with normal electric motors. Since space is very limited within the head of linear accelerators the invention proposes a new small and convenient driving/controlling device based on piezoelectricity, which is directly coupled to the leaves and their driving rods.
The multi-leaf collimator MLC for radiation therapy has leaves where the positions of the leaves are determined by measuring a magnetic field. This allows determining the leaf position with enhanced precision, and is at the same time robust to perturbations or disturbances. The magnetic sensor may comprise a magnetic encoder that varies in a predefined pattern along a lengthwise direction of the magnetic element, in particular according to a step function. The technology can be used for a new generation of especially compact and small MLC. The Hall effect sensor does not interfere with therapeutic beam and the contact-free measurements does not affected by friction or abrasive wear.
Current technologies for radiologically guided interventions leave the interventionalist with a high degree of uncertainty regarding the position of his instruments and the surrounding tissue/organs. We developed a true 4D imaging providing a full control in three spatial dimensions including temporal changes during interventions suitable for MRI and CT (single shot for lower radiation dose).