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Partial deficiency of Rspo3 leads to a significant increase of bone mass. These results indicate a major role for Rspo3 as a bone anabolic marker and/or target. Thus, Rspo3 antagonists are drug candidates for the treatment of osteopenia disorders, particularly in conditions associated with increased bone resorption.

The invention provides a long time culture model which can be used for the production of skin equivalents with a life span of at least 10 weeks.

To optimize the treatment plan for radiotherapy is time consuming and requires high memory and CPU. We developed the “Local Dose Shaping for Planning Treatment in Radiotherapy” as a method to simplify this process. The physician can use intuitive computer animation (i.e. “”dose lines can be moved by drag an drop””) to address individual local dose requirements.

The current invention provides a prophylactic HPV vaccine. Immunization against peptides from the HPV L2 protein gives a robust immune reaction that provides cross-protection against a variety of other high-risk HPV strains. Tha vaccine is based on a thioredoxin-L2 construct and can be produced in standard E. coli bacteria, which makes a cost-effective production feasible.

Rocaglamide makes tumour cells more susceptible to anti-proliferative agents while leaving normal cells unaffected. This allows dose reduction of apoptosis inducers and in parallel improves dramatically the patient’s condition during cancer treatment.

The invention provides a needle-based navigation system for CT-guided radiofrequency ablation of the liver. The key facts are: (1) Precise intervention and navigation aid for soft tissue surgery; (2) Real-time observation and supervision; (3) Inexpensive hardware/software equipment