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T-cells play key roles in many diseases: they defeat infections, attack “self” tissue in autoimmune diseases and they attack tumor tissues. T-cell antigens are in direct causal relation to pathogenesis.
Antigen determination of tissue–invasive lymphocytes: The invention is a method for the identification of T-cell epitopes of 7-10 amino acids in length (e.g. linear antigen sequence). No prior information about the nature of the antigen entity required. It is an HTS method with extremely high sensitivity (one positive cell detected in 10,000,000 negative cells within a few hours).
Laboratory experiments have been conducted with latest analytical techniques allowing to discover the reaction mechanism of autoxidation as far as possible….
The present invention HerpHu-mAb provides a humanized anti-HSV antibody that is capable of neutralising HSV infections and inhibiting the cell-to-cell spread that is crucial during HSV reactivations.
HerpHu-mAb revealed as highly effective in prevention of ocular HSV infections as well as lethal infections under immune-suppressed conditions in the corresponding animal models. Moreover, HerpHu-mAb proved to be capable of overcoming drug resistant HSV infections. Since HerpHu-mAb specifically binds to a highly conserved surface antigen that is essential for the viral fitness, the development of drug resistance is most unlikely.
Due to the high infection rates of the population and due to the frequent reactivation of the lifelong persisting virus, HSV is of particular clinical relevance. A passive immunoprophylaxis is currently not available. A couple of experimental vaccines for active immunization against HSV1 and HSV2 showed no verifiable success.
HerpHu-mAb represents a new alternative for the treatment and prevention of HSV infections that is capable of overcoming drug resistances to conventional therapies.
The Moderate Resolution Imaging Spectroradiometer or MODIS instrument aboard NASA's Aqua satellite caught a picture of Hagupit on Dec. 6 before it made…
Ionenstrahlen finden in vielen Gebieten wie Medizin, Halbleiterindustrie und auch in der Grundlagenforschung Anwendung. Hierbei werden hohe Anforderungen an die Qualität des Ionenstrahls gestellt, so dass die Bestimmung der Energie des Ionenstrahls, d.h. seine Kalibrierung, essentiell ist.
Die vorliegende Innovation beschreibt ein Messgerät und ein Verfahren um die Energie beschleunigter Ionen zu bestimmen ohne diese zu stören.
It is estimated that about 35 million people worldwide currently suffer from dementia and it is expected that the number will increase to 135 million by the…