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Alexander Disease (AxD) is a rare fatal neurodegenerative disorder that is attributed to mutations in glial fubrillary acidic protein (GFAP). Clinically, AxD is considered a type of leukoencephalopathy sometimes characterized by demyelination of the central nervous system (CNS) and the formation of GFAP-containing Rosenthal fibers in astrocytes.
While it has been shown that GFAP mutations cause AxD, the exact pathomechanism is still unknown and there is still no accepted line of treatment.
The present invention provides a new approach for AxD therapy based on the newly indentified role of GFAP in the unconventional secretory pathway (USP).
Making something new is never easy. Scientists constantly theorize about new materials, but when the material is manufactured it doesn’t always work as…
Playing the part of inspectors, the experts will have access to a wide range of sensor technologies to look for signs of whether a nuclear explosion has taken…
Raman marker as a novel labeling reagent for the selective detection of biomolecules. Their use provides three key benefits: simultaneous detection of many different target molecules, high sensitivity and quantification of the detected biomolecules
A newly developed kite system allows to alter the line length while kite surfing by around 80% of the line length. This enables new kitesurf scenarios. Due to limited shore space kitesurfer may start with short lines and bring them full length later on the water. Furthermore, while surfing, the line length can be adjusted to wind conditions. After landing, the lines can be drawn in directly avoiding winding in and tangling of leashes.
Siemens Healthcare introduces the new Prime edition of its Acuson SC2000 ultrasound system at the annual congress of the European Society of Cardiology (ESC)….