Receive funding for your R&D Projects!
Your partner for subsidy advice
Your partner for subsidy advice
The long life of lithium ion batteries makes them the rechargeable of choice for everything from implantable medical devices to wearable consumer electronics….
In the largest group of results to date, researchers from Penn Medicine's Abramson Cancer Center and other institutions have shown in clinical trials that the…
“Currently there is a severe problem with antibiotic-resistant organisms,” says Bob Hancock, a professor in UBC's Dept. of Microbiology and Immunology and lead…
<b>Background</b>
Protein kinase C zeta (PKCζ) is implicated in the development of several inflammatory diseases and a promising therapeutic target. PKCζ controls TH2 response and is important for the regulation of NF-κB transcriptional activity. Moreover, there is increasing evidence for an involvement of PKCζ in tumor development, where it controls chemoresistance and cancer–related inflammation.
<b>Invention</b>
Scientists of Saarland University and German University in Cairo have discovered 1,3,5-trisubstituted and 1,3,4,5-tetrasubstituted pyrazolines as a potent and selective class of allosteric PKCζ inhibitors. Several of the compounds show inhibitory activity in the nanomolar range. The compounds have an allosteric mode of action by binding the less conserved PIF pocked domain and are highly selective for the specific PKC isoform.
<b>Applications</b>
The present technology opens up an innovative therapeutic approach for the treatment of inflammatory diseases in which the identified compounds can serve as starting points for drug development. First experiments indicate relevance particularly for chronic obstructive pulmonary disease (COPD).
<b>Advantages</b>
• Innovative potent small molecules for selective PKCζ inhibition
• Allosteric mode of action increases selectivity
• Highly versatile scaffold for the independent optimization of four substituents
• Specific targeting may contribute to fewer side effects
• Potential treatment of diseases with high unmet medical need
Web services companies, such as Facebook, Google and Microsoft, all make promises about how they will use personal information they gather. But ensuring that…
A quantum particle can search for an item in an unsorted “database” by jumping from one item to another in superposition, and it does so faster than a…