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Production of nitrogen and phosphorus containing products in the Fischer-Tropsch synthesis

The Fischer-Tropsch synthesis is an important process to convert coal, natural gas and biomass to a variety of hydrocarbon products and oxygenates of different chain length.

In this modified Fischer-Tropsch process valuable nitrogen or phosphorous containing products of varying chain length are produced via co-feeding of suitable gases such as ammonia. These nitrogen-containing products include amines but also nitriles, amides and formamides. Amines and nitriles are important base chemicals and they are typically produced from oxygenates precursors which themselves are derived from olefins. This process therefore eliminates the use of a two-step process. Similarly phosphorous containing compounds can be produced. Moreover, the formation of oxygenates including carboxylic acids which are undesired products of the synthesis can be fully suppressed with the modified process. Notably this can be achieved with no or tolerable loss of catalyst activity.

Exotic plant species alter ecosystem productivity

In their joint publication in the journal „Ecology Letters” German and American biologists have reported an increase in biomass production in ecosystems…

Trophos announces top-line results in pivotal trial of olesoxime in spinal muscular atrophy

Trophos today announces that top-line results from a pivotal clinical trial of its lead product candidate olesoxime in spinal muscular atrophy (SMA) show a…

Penn Researchers Model a Key Breaking Point Involved in Traumatic Brain Injury

Their recent findings, published in the Biophysical Journal, shed new light on the mechanical properties of a critical brain protein and its role in the…

New LED without rare earth metal

Researchers at the University of Bremen have developed a simple method for producing zinc oxide (ZnO) nan-owires. The ZnO nanowires provide the basis for a new generation of environmentally friendly LEDs with im-proved properties.
A simple way of describing this production method would be as a baking recipe: salts and water are mixed, put into a pressure tank and placed in an oven for several hours.
By altering the temperature during the production process, different conductivities (n- and p-conducting) can be embossed to the individual nanowires and different light spectra can be defined by combining them with each other.
The production of conventional LEDs based on gallium compounds is harmful to health and calls for huge technical effort.
Zinc oxide can be produced in large quantities in an easy, cost-effective and environmentally friendly manner. It comprises efficient light-matter interaction and is transparent across almost the entire spectral range. The new LEDs have the innate potential to produce white light. Emissions in the UV range are also possible.
A prototype of the ZnO nanowire LED has been tested successfully in the laboratory. A development or cooperation partner is now being sought.

PSA-20 – Polysialic acid for the treatment of age-related macular degeneration and other neurodegenerative diseases

There is no satisfactory therapy to prevent the loss of synapses, axons or neurons in neurodegenerative diseases, such as age-related macular degeneration (AMD), multiple sclerosis and Alzheimer’s disease. Several studies demonstrate that this neuronal damage is partly mediated by proinflammatory cytokines and reactive oxygen species released by tissue macrophages and microglia.

The present invention allows preventing the production of proinflammatory cytokines and reactive oxygen species through the application of low molecular weight polysialic acid PSA-20. In vitro studies showed that PSA-20 prevents the activation of human macrophages and human microglia thereby inhibiting the production of cytotoxic proinflammatory cytokines and reactive oxygen species. It has been shown, that this anti-inflammatory effect is mediated through the human lineage specific receptor Siglec-11.

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