Studies and Analyses

Almost two out of three children with severe asthma are boys. But women account for more than two out of three adults with severe asthma. And no one really knows why. Those are some of the most striking results of a cross-sectional study of severe asthma by researchers from National Jewish Medical and Research Center being published in the October issue of the journal Chest. The research team, led by Joseph Spahn, M.D., also found that children with severe asthma had surprisingly good airflow in and

New evidence gathered in a study funded by the National Institute of Environmental Health Sciences suggests that asthmatic children who use maintenance medication are particularly vulnerable to the effects of ground-level ozone, even at levels well below the federal standard set by the Environmental Protection Agency.

Their research results were published Oct. 8 in the Journal of the American Medical Association. The study was conducted at the Yale University School of Medicine. NIEHS is on

A new study in the Oct. 9 issue of the journal Nature describes three distinct stages in the life of a memory, and helps explain how memories endure – or are forgotten – including the role that sleep plays in safeguarding memories.

“To initiate a memory is almost like creating a word processing file on a computer,” explains the study’s first author, Matthew Walker, Ph.D., instructor of psychiatry at Beth Israel Deaconess Medical Center and Harvard Medical School. “Once the file has bee

Even as the genetic blueprint for Shadow the poodle was being completed in Maryland, researchers at the University of Illinois at Urbana-Champaign had been engaged in a long-term study that they hope will add functional gene information to the dog genome as well as benefit both canine and human health.

The still-in-progress Illinois study, in which researchers are measuring the effects of diet on gene expression in both weanling and geriatric dogs, is described in a paper in the October iss

The Nuffield Council on Bioethics launches a consultation about research involving animals. Can we justify research on animals? How much do animals actually suffer? Does a mouse have a different moral status than a monkey? Who should fund research into alternatives?

Many people are concerned about the use of animals in research. There is also widespread recognition of the need for more medical research. Since much of this currently involves animals, these two views are not easily reconciled

A pattern produced by a chemical change that turns off genes in tumor cells may help predict the seriousness of a particular cancer, and perhaps its outcome.

The study by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute examined how a chemical change known as methylation spreads from one region of a breast-cancer gene to a neighboring region in tumor cells taken from patients.

The findings